Osteoblastic cell stimulation by pulsed electromagnetic fields

New Rochelle, NY, March 27, 2019-Bone fracture healing can be augmented with the application of pulsed electromagnetic fields (PEMFs), but a consensus regarding idealized conditions is lacking. A new study characterizes the in vitro effects of these PEMFs on the crucial osteoblast precursor cells and seeks to determine the optimal conditions that will promote bone regeneration. The study is published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Tissue Engineering website until April 27, 2019.

Swee-Hin Teoh, Nanyang Technological University, Singapore, presents his work with colleagues in an article titled “Effects of Electromagnetic Field on Proliferation, Differentiation and Mineralization of MC3T3 Cells”. The authors applied a daily controlled dose of pulsed electromagnetic radiation in varying duration to MC3T3-E1 osteoblast precursor cells and monitored cell viability and metabolic activity. This analysis revealed that the PEMFs increased cell proliferation either with or without osteogenic media. Calcium deposition was not enhanced by the PEMF, but osteogenic gene expression was induced. The study demonstrates that PEMF parameters must be chosen carefully to produce the desired effects for bone regeneration.

“This study confirms that pulsed electromagnetic field have indeed potential for application in bone regeneration, but the data emphasized also that a carefull selection of the PEMF parameters is required to induce a favorable effect,” says Tissue Engineering Methods Co-Editor-In-Chief Editor John A. Jansen, DDS, PhD, Professor and Head, Department of Biomaterials, Radboud University Medical Center.

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Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-in-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and John P. Fisher, PhD, Fischell Family Distinguished Professor & Department Chair, and Director of the NIH Center for Engineering Complex Tissues at the University of Maryland, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Leadership of Tissue Engineering Parts B (Reviews) and Part C (Methods) is provided by Katja Schenke-Layland, PhD, Eberhard Karls University, Tübingen, Heungsoo Shin, PhD, Hanyang University; and John A. Jansen, DDS, PhD, Radboud University, and Xiumei Wang, PhD, Tsinghua University respectively. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed on the Tissue Engineering website.

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.