• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Saturday, March 6, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Computer Modeling

Novel computer model designed to understand cardiovascular diseases

Bioengineer by Bioengineer
February 25, 2015
in Computer Modeling
1
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Researchers have developed a novel three-dimensional, multiscale and multicomponent model of endothelial cells monolayer, the inner lining of artery, to identify the cellular mechanisms involved in cardiovascular diseases (CVD). New research based on the model is able to identify the main cellular pathways involved in the initiation and progression of the disease.

heart

The model allows researchers, for the first time, to see how changes in blood flow patterns are transmitted within cell monolayers and through the cellular components. In certain regions of the vasculature, an increased permeability of the blood vessel endothelium enhances the accumulation of cholesterol-laden low-density lipoprotein (LDL) along with the transmigration of neutrophil leukocytes (white blood cells) from the bloodstream into the vessel wall inner layer. In these regions, it is believed the disturbed blood flow is linked to the cellular shape change and activation of all related mechanisms.

This model also quantifies the intracellular and intercellular mechanical stresses in a confluent vascular monolayer, for the first time. The model is able to cross the boundaries between different length scales in order to provide a global view of potential locations for the disease activated by shear forces from blood.

The model allowed the researchers to answer the questions that experiments could not answer. For example, the model estimates the forces per molecule in the cell attachment points to the external cellular matrix and cell–cell adhesion points. The research suggests that direct force-induced activation by single molecules is possible at both signaling pathways.

Model can help drug development

The model could provide a solid basis for the design of most effective therapeutics to prevent the progression of CVDs. According to Dabaghmeshin, there are a lot of medicines for the disease but not all of them are effective because they are designed to treat the causes of the CVDs but not the cellular responses to the causes.

“The root is that there are pathways that become activated by e.g., age-related wall stiffness and if we can somehow prevent that activation, then that’s the point. The drug should aim to target the cellular responses to wall stiffness, rather than stiffness itself,” Dabaghmeshin explains.

The model can be also extended to other applications from studying microfluidics to nano-materials.

Cardiovascular diseases (CVDs) are the largest cause of death in Europe and responsible for 2 million deaths per year. CVDs are one of the leading causes of long term sickness and loss to the labor market and they cost the EU economy almost 110 billion euros a year. Therefore, CVDs are a major health problem in every country in EU. CVDs are some of world’s largest health problems. According to World Health organization (WHO) they are the number one cause of death in the world accounting for 30 percent of deaths worldwide and 42% in the EU.

Story Source:

The above story is based on materials provided by Lappeenranta University of Technology, LUT.

Share12Tweet8Share2ShareShareShare2

Related Posts

blank

Computer model of blood development

February 15, 2015

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    Terahertz accelerates beyond 5G towards 6G

    668 shares
    Share 267 Tweet 167
  • People living with HIV face premature heart disease and barriers to care

    84 shares
    Share 34 Tweet 21
  • Global analysis suggests COVID-19 is seasonal

    39 shares
    Share 16 Tweet 10
  • HIV: an innovative therapeutic breakthrough to optimize the immune system

    36 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Climate ChangecancerMaterialsCell BiologyChemistry/Physics/Materials SciencesBiologyTechnology/Engineering/Computer ScienceInfectious/Emerging DiseasesPublic HealthEcology/EnvironmentMedicine/HealthGenetics

Recent Posts

  • “Magic sand” might help us understand the physics of granular matter
  • Study reveals how egg cells get so big
  • Survey identifies factors in reducing clinical research coordinator turnover
  • New ‘split-drive’ system puts scientists in the (gene) driver seat
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In