• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Saturday, June 25, 2022
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

New precision medicine tool helps optimize cancer treatment

Bioengineer by Bioengineer
December 22, 2016
in Science News
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

NEW YORK NY (December 22, 2016)–Columbia University Medical Center (CUMC) researchers have created a computational tool that can rapidly predict which genes are implicated in an individual's cancer and recommend treatments. It is among the most comprehensive tools of its kind, and the first that incorporates a user-friendly web interface that requires little knowledge of bioinformatics.

The researchers found that iCAGES identified personal cancer "drivers" 77 percent of the time when presented with a pair of randomly chosen driver genes and non-driver genes, compared with about 51 percent for other computational tools.

The study was published online today in Genome Medicine.

Most cancers are caused by the accumulation of somatic (versus inherited) genetic mutations, or variants. Many of the variants involved in numerous types of cancer have been identified with genetic sequencing studies of large numbers of patients. However, this information is not always clinically useful on an individual level. Cancer "drivers" can vary from patient to patient, and there are no practical clinical tools for predicting which variants in an individual's genome are driving his or her disease and which are present but not causing disease. "Even when the genes driving cancer are known, clinicians don't have an efficient way to choose among the hundreds of possible drug therapies," said study leader Kai Wang, PhD, associate professor of biomedical informatics and director of clinical informatics at the Institute for Genomic Medicine at CUMC.

To address this shortfall, Dr. Wang and his colleagues developed a computational tool called integrated CAncer GEnome Score (iCAGES). First, iCAGES analyzes the patient's entire genome, comparing it to the genomic sequence of the patient's tumor to identify possible cancer-causing variants. Next, iCAGES cross-references these variants to databases of known cancer-causing genes, using statistical analyses and machine learning techniques to prioritize the most likely driver genes. Finally, iCAGES matches the variants to FDA-approved and experimental drug therapies that specifically address those variants or genes. The entire process takes about 30 minutes. In contrast, conventional approaches require many separate steps involving human input, taking as long as several weeks.

In a test designed to show how the tool would be used in actual practice, Dr. Wang retrospectively tested iCAGES using detailed sequencing data from a patient with lung cancer. Out of 129 possible cancer drivers, iCAGES focused on a gene called ARAF. iCAGES used the genomic sequencing data to select sorafenib as the top drug candidate out of 122 possible treatments. The patient's oncologists had reached the same conclusions, but they used a much more complex and time-consuming approach, involving expert knowledge throughout the decision-making process. "The patient was given sorafenib and had an extraordinary clinical response," said Dr. Wang. "It's worth noting that sorafenib is not FDA-approved for this indication. Nonetheless, the result suggests that iCAGES may help to identify novel treatment strategies and off-label use of existing approved drugs."

When tested on various cancer patient databases, iCAGES was found to be superior to other computational tools at predicting cancer drivers from personal genomes and at identifying beneficial treatment.

"We hope that iCAGES can help clinicians take full advantage of the massive amounts of data on genomic sequencing and cancer variants, and shed light on personalized cancer therapy," said Dr. Wang.

A pilot clinical trial is now being planned to evaluate the translational potential of iCAGES. Clinicians and researchers can access the tool at icages.wglab.org.

###

The study is titled, "iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes." The other contributors are: Chengliang Dong (University of Southern California, Los Angeles, CA), Yunfei Guo (University of Southern California), Hui Yang (University of Southern California), Zeyu He (New York University, New York, NY), and Xiaoming Liu (University of Texas Health Science Center at Houston, Houston, TX).

The study was supported by grants from the National Institutes of Health (HG006465 and MH108728).

Previously, Dr. Wang was a board member and shareholder in Tute Genomics, a bioinformatics software company. The remaining authors declare that they have no competing interests.

Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. The campus that Columbia University Medical Center shares with its hospital partner, NewYork-Presbyterian, is now called the Columbia University Irving Medical Center. For more information, visit cumc.columbia.edu or columbiadoctors.org.

Media Contact

Karin Eskenazi
[email protected]
212-342-0508
@ColumbiaMed

http://www.cumc.columbia.edu

############

Story Source: Materials provided by Scienmag

Share12Tweet7Share2ShareShareShare1

Related Posts

Built infrastructure, hunting and climate change linked to huge migratory bird declines

Built infrastructure, hunting and climate change linked to huge migratory bird declines

June 25, 2022
Biofinder images

Biofinder advances detection of extraterrestrial life

June 24, 2022

Flawed AI makes robots racist, sexist

June 24, 2022

Spiral wave teleportation theory offers new path to defibrillate hearts, terminate arrhythmias

June 24, 2022
Please login to join discussion

POPULAR NEWS

  • Pacific whiting

    Oregon State University research finds evidence to suggest Pacific whiting skin has anti-aging properties that prevent wrinkles

    36 shares
    Share 14 Tweet 9
  • University of Miami Rosenstiel School selected for National ‘Reefense’ Initiative focusing on Florida and the Caribbean

    35 shares
    Share 14 Tweet 9
  • Saving the Mekong delta from drowning

    37 shares
    Share 15 Tweet 9
  • Sharks may be closer to the city than you think, new study finds

    34 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

WeaponryVaccinesWeather/StormsVaccineUrbanizationUrogenital SystemVirusVehiclesUniversity of WashingtonVirologyViolence/CriminalsZoology/Veterinary Science

Recent Posts

  • Built infrastructure, hunting and climate change linked to huge migratory bird declines
  • Biofinder advances detection of extraterrestrial life
  • Flawed AI makes robots racist, sexist
  • Spiral wave teleportation theory offers new path to defibrillate hearts, terminate arrhythmias
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Posting....