• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Wednesday, September 10, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

New osteoporosis therapy’s dual effects on bone tissue

Bioengineer by Bioengineer
June 25, 2019
in Health
Reading Time: 2 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Dr. Pascale Chavassieux

Sclerostin is a protein produced by osteocytes in the bone that inhibits bone formation. A recent analysis of results from a clinical trial reveals the beneficial effects of romosozumab, an antibody therapy that targets sclerostin, on bone tissue in postmenopausal women with osteoporosis. The findings are published in the Journal of Bone and Mineral Research.

Romosozumab increases serum markers of bone formation and decreases those of bone breakdown, or resorption. This is associated with an increased bone mineral density and a reduced risk of bone fractures.

This latest analysis included 107 patients with osteoporosis who were enrolled in the multicenter, phase 3 clinical trial called the Fracture Study in Postmenopausal Women with Osteoporosis (FRAME) study and who underwent bone biopsies. The analysis showed that at the tissue level, romosozumab produced an early and transient increase in bone formation and a persistent decrease in bone resorption. This led to significant increases in bone mass and improved bone microarchitecture (Figure) after 12 months of therapy. These effects contribute to the reduced fracture risk previously reported in postmenopausal women with osteoporosis treated with romosozumab.

“Romosozumab is the first osteoporosis therapy with a dual effect on bone tissue, increasing bone formation and decreasing resorption” said lead author Dr. Pascale Chavassieux, of the University of Lyon, in France.

###

Media Contact
Penny Smith
[email protected]

Related Journal Article

http://dx.doi.org/10.1002/jbmr.3735

Tags: Medicine/HealthMusculatureOrthopedic MedicinePublic Health
Share12Tweet8Share2ShareShareShare2

Related Posts

Enhancing Transitions for Youth with Eating Disorders

September 10, 2025

Strong Link Between Dementia Risk and Multiple Co-Existing Mental Health Disorders Revealed

September 10, 2025

Revolutionizing Blood Pumps: Customized Ventricular Assist Device Insights

September 9, 2025

Mayo Clinic Physician Honored with Dr. Scott C. Goodwin Grant for Advancing Adenomyosis Research

September 9, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    151 shares
    Share 60 Tweet 38
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    116 shares
    Share 46 Tweet 29
  • Physicists Develop Visible Time Crystal for the First Time

    51 shares
    Share 20 Tweet 13
  • First Confirmed Human Mpox Clade Ib Case China

    56 shares
    Share 22 Tweet 14

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Enhancing Transitions for Youth with Eating Disorders

Insatiable Star Devours Its Cosmic Twin at Unprecedented Rate

Breast Cell Changes During Motherhood Offer Insights into Breastfeeding Challenges

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.