• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Monday, September 29, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

New formulation of existing medicines prove highly effective against drug-resistant fungus

Bioengineer by Bioengineer
April 7, 2021
in Chemistry
Reading Time: 3 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: CWRU

CLEVELAND–A team of researchers from Case Western Reserve University has discovered a formulation of existing medicines that can significantly reduce the presence of the fungus Candida auris (C. auris) on skin, controlling its spread and potentially keeping it from forming infections that have a high mortality rate.

By using a proprietary formulation of topical medications terbinafine or clotrimazole, researchers prevented the growth and spread of the fungus on the skin of a host; the findings appear in the most recent issue of the journal Antimicrobial Agents and Chemotherapy.

“It’s a very difficult fungus to kill because it is highly resistant and opportunistic–generally taking hold in those whose immune systems are already battling other threats,” said Mahmoud Ghannoum, who led the research as director of the Center for Medical Mycology at the Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center. “It’s promising that we were able to decolonize–get rid of the fungus from the skin–with a unique formulation of medicines that have already been approved and are available.”

The U.S. Centers for Disease Control (CDC) has identified the fungus as a serious threat to public health because of its resistance to treatment by existing drugs. The fungus was first found in Japan in 2009 and has since been detected in India, the United States and other countries. The mortality rate from infection is about 60%, according previously published research.

C. auris infections often occur in hospitals–with the fungus living undetected, even on the skin of recovering patients, as well as clothing, bedding and other surfaces. Many who get infected are immunocompromised, including patients on antibiotics, which can suppress the presence of good bacteria to help fight the fungus.

Identifying the fungus and diagnosing the infections it causes have been difficult. But emerging molecular-testing methods that can definitively detect the organism are becoming more widespread, Ghannoum said.

“Our results could prove to be one leg of the stool in stopping this unique threat,” he said. “While there are many types of bacteria resistant to medicines, C. auris stands alone in this respect among fungi–creating significant challenges for treatment or eradication where it’s taken hold.”

In this study, researchers tested the proprietary formulation of medicines–a novel transdermal mixture of 1% terbinafine or 1% clotrimazole created with an emerging method known as “Advanced Penetration Technology”–on the skin of mice. Researchers are next seeking approval to test the blend of medications on human volunteers.

“As the only fungus that is multidrug resistant, we still have a lot to learn, especially in how widespread C. auris is in our health care settings,” said Ghannoum, who is also the Marti D. and Jeffrey S. Davis Family Master Clinician in Cancer Innovation. “We feel encouraged that our findings are a piece of the puzzle in solving this serious health threat worldwide.”

###

Co-authors of the research, “A Novel Transdermal Application for Clearing Skin Colonization by Candida auris,” are Thomas McCormick, associate professor in the Department of Dermatology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center (UH); Lisa Long, a research assistant at the CWRU School of Medicine; and Janet L. Herrada, a research assistant at Case Western Reserve and UH.

The study was supported by a grant from the National Institutes of Health and funding from private companies.

Media Contact
Daniel Robison
[email protected]

Original Source

https://thedaily.case.edu/new-formulation-of-existing-medicines-prove-highly-effective-against-drug-resistant-fungus/

Tags: DermatologyImmunology/Allergies/AsthmaMedicine/HealthPharmaceutical ChemistryPharmaceutical Science
Share12Tweet8Share2ShareShareShare2

Related Posts

New Study Uncovers Why Modern Proteins Were Selected by Nature

New Study Uncovers Why Modern Proteins Were Selected by Nature

September 29, 2025

Global Call to Advance Robust and Reproducible Polyphenol Research to Launch Next October in Malta at Polyphenols Applications World Congress and Iprona

September 29, 2025

Physicists Narrow the Search for Elusive Dark Matter

September 29, 2025

Lab Breakthrough in Mimicking Star Formation Wins Prestigious John Dawson Award

September 29, 2025
Please login to join discussion

POPULAR NEWS

  • New Study Reveals the Science Behind Exercise and Weight Loss

    New Study Reveals the Science Behind Exercise and Weight Loss

    87 shares
    Share 35 Tweet 22
  • Physicists Develop Visible Time Crystal for the First Time

    73 shares
    Share 29 Tweet 18
  • How Donor Human Milk Storage Impacts Gut Health in Preemies

    58 shares
    Share 23 Tweet 15
  • Scientists Discover and Synthesize Active Compound in Magic Mushrooms Again

    56 shares
    Share 22 Tweet 14

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Advancing Lithium-Ion Batteries Through Solvation Engineering

Cipepofol: Safe, Effective for Elderly Digestive Endoscopy

Advancing Neonatal Nephrology: Insights from First Symposium

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 60 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.