• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Sunday, March 26, 2023
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

New evidence shows how bacterium in undercooked chicken causes GBS

Bioengineer by Bioengineer
December 9, 2016
in Science News
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Credit: G.L. Kohuth, Michigan State University

A Michigan State University research team is the first to show how a common bacterium found in improperly cooked chicken causes Guillain-Barre Syndrome, or GBS.

The federally funded research, now published in the Journal of Autoimmunity, not only demonstrates how this food-borne bacterium, known as Campylobacter jejuni, triggers GBS, but offers new information for a cure.

If chicken isn't cooked to the proper minimum internal temperature, bacteria can still exist.

"What our work has told us is that it takes a certain genetic makeup combined with a certain Campylobacter strain to cause this disease," said Linda Mansfield, lead author and MSU College of Veterinary Medicine professor. "The concerning thing is that many of these strains are resistant to antibiotics and our work shows that treatment with some antibiotics could actually make the disease worse."

GBS is the world's leading cause of acute neuromuscular paralysis in humans and despite much speculation, the exact mechanisms of how this autoimmune disease develops have been widely unknown.

"We have successfully produced three preclinical models of GBS that represent two different forms of the syndrome seen in humans," Mansfield said. "Our models now provide a unique opportunity to understand how your personal genetic type may make you more susceptible to certain forms of GBS."

Another area of concern more recently among scientists is related to an increase of the disease due to the Zika virus. Mansfield said there are many other bacteria and viruses associated with GBS and her models and data could be useful in studying these suspected causes, as well as finding better treatment and prevention options.

Despite the severity of GBS, treatments have been very limited and fail in many cases. In fact, the use of certain antibiotics in Mansfield's study aggravated neurological signs, lesions and the number of immune antibodies that can mistakenly attack a patient's own organs and tissues.

"These models hold great potential for discovery of new treatments for this paralysis," Mansfield said. "Many patients with GBS are critically ill and they can't participate in clinical trials. The models we identified can help solve this."

Those suffering from GBS can initially experience vomiting and diarrhea, but can often write the symptoms off as eating bad food. One to three weeks later, they can begin to develop weakness and tingling in the feet and legs. Gradually, paralysis can spread to the upper body and arms, and even a respirator may be needed for breathing.

Mansfield now wants to move forward quickly to test drugs against GBS in her models.

"Of course new treatments would be wonderful," she said, "but therapeutics to prevent GBS from developing in the first place would be the best strategy so that people don't have to suffer with paralysis."

Campylobacter jejuni infects more than a million people yearly in the United States and is also known to trigger other autoimmune disorders such as Inflammatory Bowel Disease and Reiter's arthritis.

###

The National Institutes of Health Enterics Research Investigational Network, or ERIN, funded the research.

Michigan State University has been working to advance the common good in uncommon ways for more than 150 years. One of the top research universities in the world, MSU focuses its vast resources on creating solutions to some of the world's most pressing challenges, while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

Media Contact

Sarina Gleason
[email protected]
517-355-9742
@MSUnews

http://msutoday.msu.edu/journalists/

############

Story Source: Materials provided by Scienmag

Share12Tweet7Share2ShareShareShare1

Related Posts

Picture1.png

Is early rhythm control in atrial fibrillation care cost-effective?

March 25, 2023
Transitions of low and high-entropy metal tellurides.

“Glassiness” and “blurriness” might explain the behavior of high-entropy superconductors

March 25, 2023

Illinois Tech Assistant Professor Ren Wang receives prestigious National Science Foundation Award

March 24, 2023

New type of entanglement lets scientists ‘see’ inside nuclei

March 24, 2023
Please login to join discussion

POPULAR NEWS

  • ChatPandaGPT

    Insilico Medicine brings AI-powered “ChatPandaGPT” to its target discovery platform

    65 shares
    Share 26 Tweet 16
  • Northern and southern resident orcas hunt differently, which may help explain the decline of southern orcas

    44 shares
    Share 18 Tweet 11
  • Skipping breakfast may compromise the immune system

    43 shares
    Share 17 Tweet 11
  • Insular dwarfs and giants more likely to go extinct

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Is early rhythm control in atrial fibrillation care cost-effective?

“Glassiness” and “blurriness” might explain the behavior of high-entropy superconductors

Illinois Tech Assistant Professor Ren Wang receives prestigious National Science Foundation Award

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 48 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In