• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Wednesday, April 21, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

Monoclonal antibody drug superior to chemotherapy for advanced acute lymphoblastic leukemia

Bioengineer by Bioengineer
March 1, 2017
in Science News
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Credit: MD Anderson Cancer Center

HOUSTON — A Phase III clinical trial involving 101 centers in 21 countries revealed the monoclonal antibody blinatumomab to be more effective than standard chemotherapy for treatment of advanced acute lymphoblastic leukemia (ALL). Study findings were published in the March 1 online issue of the New England Journal of Medicine.

The study, led by The University of Texas MD Anderson Cancer Center, randomly assigned 405 patients 18 years or older to groups receiving either blinatumomab or chemotherapy. Overall survival was significantly longer in the blinatumomab group with median survival of 7.7 months versus four months for those on chemotherapy. Remission rates within 12 weeks after treatment began were higher in the blinatumomab group with complete remission rates of 34 percent reported in this group versus 16 percent for those on chemotherapy. The study also showed that patients treated with blinatumomab had a lower rate of adverse effects.

While the prognosis for newly diagnosed ALL has improved over the last three decades with intensive chemotherapy regimens resulting in complete remission rates of 85 to 90 percent and long-term survival rates of 30 to 50 percent, most adult patients with the B-cell precursor ALL, the most common form, ultimately relapse and die from disease complications. The accepted standard of care is to help the patient maintain remission long enough to receive allogeneic or donor stem-cell transplantation, considered the most effective therapy.

"Among adults with relapsed ALL, remission rates are18 to 44 percent with standard chemotherapy but the duration of remission is typically short. A major goal for these patients is to induce remission with sufficient duration to prepare for stem-cell transplantation," said Hagop Kantarjian, M.D., chair of the Department of Leukemia, and lead author for the New England Journal of Medicine paper. "In this study, 24 percent of patients in each treatment group underwent allogeneic stem cell transplantation."

Blinatumomab, developed by Amgen, works by binding simultaneously to specific cytotoxic T-cells and B-cells, which allows the patient's healthy T-cells to recognize and eliminate cancer stem cells called blasts.

"The activity of an immune-based therapy such as blinatumomab, which depends on functioning T-cells for its activity, provides encouragement that responses may be further enhanced and made durable with additional immune activation strategies," said Kantarjian.

The study, designed and funded by Amgen, did not include patients who had other active cancers, relevant central nervous system conditions, autoimmune disease, acute or chronic graft-versus-host disease, chemotherapy or radiotherapy within two weeks before the study, donor stem cell transplantation within 12 weeks before the trial or autologous stem cell transplantation within six week preceding the study. Patients who received immunotherapy in the month before the trial or who were undertaking other investigational treatments were also excluded.

###

Authors from the paper include investigators from City of Hope National Medical Center, Duarte, Calif.; Amgen, Thousand Oaks, Calif. and Washington D.C.; Frankfurt am Main University Hospital Schleswig Holstein, Kiel, Germany; Mediziniche Klinik und Poliklinik II, Universitätsklinikums, Wurzburg, Germany; Princess Margaret Cancer Centre, Toronto; Hôpital Maisonneuve-Rosemont, Montreal; Universitat Autonoma de Barcelona and the University of Valencia, Spain; Alfred Hospital and Monash University, Melbourne, Australia; Hôpital Saint-Louis, Paris; Centre Hospitalier Lyon Sud, Pierre-Benite, France; Universitá Sapienza di Roma, Rome; Aziendo Unitá Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo, Venice, Italy; Universitá Statale di Milano, Milan; Ankara Universitesi, Ankara, and Dokuz Eylul Universitesi Tip Facultesi, Izmir, both in Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medcyzne Kszta?cenia Podyplomowego, Warsaw, Poland; and the University of Washington Medical Center, Seattle.

Media Contact

Ron Gilmore
[email protected]
713-745-1898
@mdandersonnews

http://www.mdanderson.org

############

Story Source: Materials provided by Scienmag

Share12Tweet7Share2ShareShareShare1

Related Posts

IMAGE

Study: ‘Fingerprint’ for 3D printer accurate 92% of time

April 21, 2021
IMAGE

Microplastics affect global nutrient cycle and oxygen levels in the ocean

April 21, 2021

Direct observation of the ad- and desorption of guest atoms into a mesoporous host

April 21, 2021

Great white feeding ground

April 21, 2021

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    A sturdier spike protein explains the faster spread of coronavirus variants

    44 shares
    Share 18 Tweet 11
  • UofL, Medtronic to develop epidural stimulation algorithms for spinal cord injury

    56 shares
    Share 22 Tweet 14
  • Jonathan Wall receives $1.79 million to develop new amyloidosis treatment

    61 shares
    Share 24 Tweet 15
  • New evidence in search for the mysterious Denisovans

    34 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

VehiclesVaccinesUrbanizationVaccineVirologyVirusWeaponryWeather/StormsUniversity of WashingtonZoology/Veterinary ScienceViolence/CriminalsUrogenital System

Recent Posts

  • Study: ‘Fingerprint’ for 3D printer accurate 92% of time
  • Microplastics affect global nutrient cycle and oxygen levels in the ocean
  • Direct observation of the ad- and desorption of guest atoms into a mesoporous host
  • Great white feeding ground
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In