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Home NEWS Science News Biology

Many human genomes shaped by past events that caused sharp dips in the population

Bioengineer by Bioengineer
June 23, 2022
in Biology
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The genomes of many human populations show evidence of founder events, which occur when a small number of initial members start a new population, and can lead to low genetic diversity as well as increase the risk of certain genetic diseases in the new population. Rémi Tournebize and Priya Moorjani of the University of California, Berkeley, U.S. report these new findings June 23rd in the open access journal PLOS Genetics.

Many human genomes shaped by past events that caused sharp dips in the population

Credit: Rémi Tournebize and Priya Moorjani (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/)

The genomes of many human populations show evidence of founder events, which occur when a small number of initial members start a new population, and can lead to low genetic diversity as well as increase the risk of certain genetic diseases in the new population. Rémi Tournebize and Priya Moorjani of the University of California, Berkeley, U.S. report these new findings June 23rd in the open access journal PLOS Genetics.

Founder events can occur when a population experiences a sharp decrease in numbers or when a few individuals colonize an isolated environment, such as an island. Despite the large impact that founder events can have on a population’s genetics, we know few details of how these events have shaped the evolution of humans and other species. To better understand these past events, researchers developed a new technique called ASCEND that uses genomic analysis to estimate the timing and strength of founder events. In the new study, they applied ASCEND to analyze about 460 human populations worldwide. The researchers found that over half of the populations that they analyzed had evidence of recent founder events, including most living hunter-gatherer, nomadic and indigenous groups that were sampled. These founder events are associated with geographic isolation, a hunter-gatherer lifestyle, or the cultural practice of marrying within your own group or religion.

The researchers also analyzed about 200 modern dog populations and found that most populations show signs of extreme founder events. These events occurred within the last 25 generations, coinciding with the start of dog breeding during Victorian times, and may be related to inbreeding and the use of a few highly prized males to sire numerous litters.

The new analysis technique will help scientists to identify groups that experienced strong founder events and that may be at high risk of certain genetic diseases. Ashkenazi Jews and Finns, who experienced strong founder events, often undergo genetic screening to learn about their pre-disposition to certain genetic diseases. The study found that several populations among Native Americans, Oceanians, and South Asians have experienced even more extreme founder events than Ashkenazi Jews, and so these populations may also benefit from genetic screening.

Tournebize and Moorjani add, “Some human populations like Ashkenazi Jews or Finns have been extensively studied in population genetics and have helped researchers identify many disease-causing mutations. Hence, we wanted to study if other populations have a similar history that could enable further progress in medical genetics. We were surprised to see how widespread the history of founder events is in humans, both in present-day and ancient DNA samples, suggesting that investigation of disease-causing variants will be fruitful to identify and reduce disease burden among contemporary groups.”

#####

In your coverage, please use this URL to provide access to the freely available article in PLOS Genetics: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010243

Citation: Tournebize R, Chu G, Moorjani P (2022) Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals. PLoS Genet 18(6): e1010243. https://doi.org/10.1371/journal.pgen.1010243

Author Countries: United States

Funding: RT was supported by the UC Departmental Startup funds awarded to PM. PM has support from the Burroughs Wellcome Fund Careers at the Scientific Interface, Sloan Research Fellowship, and NIH R35GM142978. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.



Journal

PLoS Genetics

DOI

10.1371/journal.pgen.1010243

Method of Research

Observational study

Subject of Research

People

COI Statement

Competing interests: The authors have declared that no competing interests exist.

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