• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Thursday, June 1, 2023
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Maintaining normal serum potassium levels in peritoneal dialysis may reduce risk of peritonitis

Bioengineer by Bioengineer
May 18, 2022
in Biology
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

This prospective, multicenter, randomized controlled trial published in the American Journal of Kidney Diseases (AJKD) demonstrated that, compared with a reactive strategy of potassium supplementation when serum potassium fell below 3.5 mEq/L, a protocol-based potassium supplementation strategy to maintain serum potassium in the target range of 4-5 mEq/L resulted in a longer time (90 days) to the first peritonitis episode, a lower hazard ratio of peritonitis, and a lesser proportion of free-peritonitis participants.

Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis

Credit: Pitchitporn et al, AJKD 2022

This prospective, multicenter, randomized controlled trial published in the American Journal of Kidney Diseases (AJKD) demonstrated that, compared with a reactive strategy of potassium supplementation when serum potassium fell below 3.5 mEq/L, a protocol-based potassium supplementation strategy to maintain serum potassium in the target range of 4-5 mEq/L resulted in a longer time (90 days) to the first peritonitis episode, a lower hazard ratio of peritonitis, and a lesser proportion of free-peritonitis participants.

Hypokalemia is commonly found in patients on peritoneal dialysis (PD) and associated with poor outcomes. A multicenter, open-label, prospective, randomized controlled trial was conducted in 167 hypokalemic patients receiving PD. It examined if a protocol-based correction of hypokalemia to maintain serum potassium 4-5 mEq/L (85 participants) could improve PD-related outcomes compared to reactive potassium supplementation administered when serum potassium levels fell below 3.5 mEq/L (82 participants). During the median follow-up time of 401 days, the protocol supplementation appeared safe and significantly reduced the risk of peritonitis. Potassium chloride tablets at the dosage used in this study (25±13 mEq/day) demonstrated promising efficacy and relatively few side effects. Most participants in the study tolerated the medications well, with only a tiny number discontinuing treatment due to adverse effects. Notably, only 4% of participants in the intervention group experienced asymptomatic hyperkalemia. 

 

TITLE: Efficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial

AUTHORS: Watthikorn Pichitporn, MD, Talerngsak Kanjanabuch, MD, Jeerath Phannajit, MD, Pongpratch Puapatanakul, MD, Piyatida Chuengsaman, MD, Watanyu Parapiboon, MD, Worapot Treamtrakanpon, MD, Chanchana Boonyakrai, MD, Saraporn Matayart, MD, Pisut Katavetin, MD, Jeffrey Perl, MD, Kearkiat Praditpornilpa, MD, Somchai Eiam-Ong, MD, Kriang Tungsanga, MD, and David W. Johnson, MD

DOI: https://doi.org/10.1053/j.ajkd.2022.03.013



Journal

American Journal of Kidney Diseases

DOI

10.1053/j.ajkd.2022.03.013

Article Title

Efficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial

Article Publication Date

18-May-2022

Share12Tweet8Share2ShareShareShare2

Related Posts

Characterization of morphological and biological aspects of venomous caterpillars of the genus Lonomia Walker (Lepidoptera: Saturniidae) in Colombia

Researchers describe the life cycle of four species of the world’s most venomous caterpillars, genus Lonomia Walker, and discover new parasitoids and host plants

May 31, 2023
Drying codfish

Overfishing linked to rapid evolution of codfish

May 31, 2023

Computational biologist Tal Einav joins LJI faculty

May 31, 2023

Paleontologists discover elephant graveyard in North Florida

May 31, 2023

POPULAR NEWS

  • plants

    Plants remove cancer causing toxins from air

    40 shares
    Share 16 Tweet 10
  • Element creation in the lab deepens understanding of surface explosions on neutron stars

    36 shares
    Share 14 Tweet 9
  • Groundbreaking study uncovers first evidence of long-term directionality in the origination of human mutation, fundamentally challenging Neo-Darwinism

    115 shares
    Share 46 Tweet 29
  • How life and geology worked together to forge Earth’s nutrient rich crust

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

DNA damage repaired by antioxidant enzymes

Petit-spot volcanoes involve the deepest known submarine hydrothermal activity, possibly release CO2 and methane

Producing large, clean 2D materials made easy: just KISS

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 50 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In