• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Tuesday, June 6, 2023
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Key advance in neurological disorder pre-clinical testing

Bioengineer by Bioengineer
February 17, 2022
in Biology
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Australian neurobiologists and material scientists have teamed up to innovate the petri-dish to be able to grow and age live brain cells from patients with neurological disorders. 

PhD Bridget Milky

Credit: Flinders University

Australian neurobiologists and material scientists have teamed up to innovate the petri-dish to be able to grow and age live brain cells from patients with neurological disorders. 

The key advance by experts at Flinders University and South Australian Health and Medical Research Institute (SAHMRI) is a critical element in achieving targeted drug treatments for individuals and could enhance future studies on conditions ranging from dementia, Parkinson’s, epilepsy, autism and mental health.

In recent years researchers around the world have managed to turn patients’ skin cells into induced pluripotent stem cells and brain cells. This Nobel Prize winning breakthrough gives new hope for neurological therapeutic discoveries, which are notoriously difficult due to limited access to patient brains. However much still need to be accomplished to make this lab model as realistic and effective as possible.

Assisted by a recent $1 million injection of funding led by the Michael J Fox Foundation, Shake it up Foundation and The Hospital Research Foundation, the Bardy Lab has published the latest developments in Stem Cell Reports and will scale up the approach to test new potential treatments for Parkinson’s disease, brain cancer and a form a childhood dementia.

“Along with our patented BrainPhys medium, this new substrate will significantly improve laboratory testing on human brain cells. Advancing patient-specific pre-clinical research is so important for so many people both young and older who currently suffer from brain disorders and may not have time to wait for expensive and lengthy clinical trials with very slim chance of success,” says Associate Professor Cedric Bardy. 

“I believe testing drugs on patient cells before enrolling clinical trials will be a game-changer for medical discoveries, but we need to get the model right. This study takes us closer to this goal.”

“The new substrate applied to petri dishes maintains complex electrical connections between neurons, allowing us to model the patient’s brain more accurately and  determine the best treatment with more certainty,” says first author PhD candidate Bridget Milky.

The new substrate will be manufactured by Adelaide biotech TekCyte Limited, with company director Tony Simula involved in its development. 

“We look forward to improving pharmaceuticals and research laboratory systems to potentially shave precious years off finding the best treatment for people living with diseases such as Parkinson’s,” Mr Simula says.

The article, Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings (2022) by Bridget Milky, Michael Zabolocki, Sameer A Al-Bataineh, Mark van den Hurk, Zarina Greenberg, Lucy Turner, Paris Mazzachi, Amber Williams, Imanthi Illeperuma, Robert Adams, Brett Stringer, Rebecca Ormsby, Santosh Poonnoose, Louise E Smith, Marta Krasowska, Jason D Whittle, Tony Simula and Cedric Bardy has been published in Stem Cell Reports DOI: 10.1016/j.stemcr.2022.01.013.

 



Journal

Stem Cell Reports

DOI

10.1016/j.stemcr.2022.01.013

Method of Research

Experimental study

Subject of Research

People

Article Title

Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings

Article Publication Date

17-Feb-2022

COI Statement

The authors declare no conflict of interest

Share12Tweet8Share2ShareShareShare2

Related Posts

Feedback Loop

The other side of the story: How evolution impacts the environment

June 5, 2023
African BioGenome Project (AfricaBP) Open Institute for Genomics and Bioinformatics Southern Africa Workshop Poster 2023

African BioGenome Project (AfricaBP) Open Institute for Genomics and Bioinformatics Workshop 2023

June 5, 2023

Weather anomalies are keeping insects active longer

June 5, 2023

Scientists expand understanding of limb evolution in earliest birds

June 5, 2023

POPULAR NEWS

  • plants

    Plants remove cancer causing toxins from air

    41 shares
    Share 16 Tweet 10
  • Element creation in the lab deepens understanding of surface explosions on neutron stars

    36 shares
    Share 14 Tweet 9
  • Deep sea surveys detect over five thousand new species in future mining hotspot

    35 shares
    Share 14 Tweet 9
  • How life and geology worked together to forge Earth’s nutrient rich crust

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Mount Sinai researchers use new deep learning approach to enable analysis of electrocardiograms as language

Ba2LuAlO5: A new proton conductor for next-generation fuel cells

Programmable 3D printed wound dressing could improve treatment for burn, cancer patients

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 50 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In