Key advance in neurological disorder pre-clinical testing

Australian neurobiologists and material scientists have teamed up to innovate the petri-dish to be able to grow and age live brain cells from patients with neurological disorders. 

The key advance by experts at Flinders University and South Australian Health and Medical Research Institute (SAHMRI) is a critical element in achieving targeted drug treatments for individuals and could enhance future studies on conditions ranging from dementia, Parkinson’s, epilepsy, autism and mental health.

In recent years researchers around the world have managed to turn patients’ skin cells into induced pluripotent stem cells and brain cells. This Nobel Prize winning breakthrough gives new hope for neurological therapeutic discoveries, which are notoriously difficult due to limited access to patient brains. However much still need to be accomplished to make this lab model as realistic and effective as possible.

Assisted by a recent $1 million injection of funding led by the Michael J Fox Foundation, Shake it up Foundation and The Hospital Research Foundation, the Bardy Lab has published the latest developments in Stem Cell Reports and will scale up the approach to test new potential treatments for Parkinson’s disease, brain cancer and a form a childhood dementia.

“Along with our patented BrainPhys medium, this new substrate will significantly improve laboratory testing on human brain cells. Advancing patient-specific pre-clinical research is so important for so many people both young and older who currently suffer from brain disorders and may not have time to wait for expensive and lengthy clinical trials with very slim chance of success,” says Associate Professor Cedric Bardy. 

“I believe testing drugs on patient cells before enrolling clinical trials will be a game-changer for medical discoveries, but we need to get the model right. This study takes us closer to this goal.”

“The new substrate applied to petri dishes maintains complex electrical connections between neurons, allowing us to model the patient’s brain more accurately and  determine the best treatment with more certainty,” says first author PhD candidate Bridget Milky.

The new substrate will be manufactured by Adelaide biotech TekCyte Limited, with company director Tony Simula involved in its development. 

“We look forward to improving pharmaceuticals and research laboratory systems to potentially shave precious years off finding the best treatment for people living with diseases such as Parkinson’s,” Mr Simula says.

The article, Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings (2022) by Bridget Milky, Michael Zabolocki, Sameer A Al-Bataineh, Mark van den Hurk, Zarina Greenberg, Lucy Turner, Paris Mazzachi, Amber Williams, Imanthi Illeperuma, Robert Adams, Brett Stringer, Rebecca Ormsby, Santosh Poonnoose, Louise E Smith, Marta Krasowska, Jason D Whittle, Tony Simula and Cedric Bardy has been published in Stem Cell Reports DOI: 10.1016/j.stemcr.2022.01.013.