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Home NEWS Science News Chemistry

Kessler Foundation study advances knowledge of role of brain pathology and cognitive fatigue in multiple sclerosis

Bioengineer by Bioengineer
September 30, 2022
in Chemistry
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East Hanover, NJ. September 30, 2022. Using advanced diffusion neuroimaging technology, Kessler Foundation researchers investigated the relationship between the rate of cognitive fatigue to microstructural changes in the brain in persons with multiple sclerosis. Their findings help fill a gap in the current understanding of how brain pathology influences the development of fatigue over time.

Rocco Ortenzio Neuroimaging Center at Kessler Foundation

Credit: Kessler Foundation

East Hanover, NJ. September 30, 2022. Using advanced diffusion neuroimaging technology, Kessler Foundation researchers investigated the relationship between the rate of cognitive fatigue to microstructural changes in the brain in persons with multiple sclerosis. Their findings help fill a gap in the current understanding of how brain pathology influences the development of fatigue over time.

Their findings were reported in Frontiers in Neurology on July 04, 2022, in the open access article “Associations of White Matter and Basal Ganglia Microstructure to Cognitive Fatigue Rate in Multiple Sclerosis,” (doi: 10.3389/fneur.2022.911012). The authors are Cristina Almeida Flores Román, PhD, Glenn Wylie, DPhil, John DeLuca, PhD, and Bing Yao, PhD, and of Kessler Foundation.

The study was conducted at the Rocco Ortenzio Neuroimaging Center at Kessler Foundation, which is dedicated solely to rehabilitation research. Participants were 62 individuals with relapsing-remitting MS. All completed questionnaires measuring depression, state and trait anxiety, and trait fatigue. While in the scanner, participants underwent a cognitively fatiguing task. In addition to measuring rate of cognitive fatigue, researchers measured whole brain lesion volume and performance during the fatigue-inducing task.

“We found that the cognitive rate related to white matter tracts, many with associations with the basal ganglia or what we have proposed as the ‘fatigue network’,” said lead author Dr. Román, National MS Society postdoctoral fellow at Kessler Foundation. “These findings bring us closer to understanding how brain pathology impacts the experience in the moment. This is fundamental to developing effective interventions for managing the disabling fatigue of MS and other neurological conditions.”

Funding: Kessler Foundation, National Multiple Sclerosis Society (RG-1701-26930) 

Learn more about ongoing studies at Kessler Foundation at Join Our Research Studies | Kessler Foundation

About Kessler Foundation

Kessler Foundation, a major nonprofit organization in the field of disability, is a global leader in rehabilitation research that improves cognition, mobility, and long-term outcomes, including employment, for people with neurological disabilities caused by diseases and injuries of the brain and spinal cord. Kessler Foundation leads the nation in funding innovative programs that expand opportunities for employment for people with disabilities. Learn more by visiting http://www.KesslerFoundation.org

Stay Connected

Twitter | http://Twitter.com/KesslerFdn 
Facebook | http://Facebook.com/KesslerFoundation 
YouTube | http://Youtube.com/user/KesslerFoundation 
Instagram | http://Instagram.com/kesslerfdn

iTunes & SoundCloud | http://Soundcloud.com/kesslerfoundation

To interview an expert, contact:

Deborah Hauss, [email protected]

Carolann Murphy,  [email protected]

 



Journal

Frontiers in Neurology

DOI

10.3389/fneur.2022.911012

Method of Research

Imaging analysis

Subject of Research

People

Article Title

Associations of White Matter and Basal Ganglia Microstructure to Cognitive Fatigue Rate in Multiple Sclerosis

Article Publication Date

4-Jul-2022

COI Statement

none

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