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Home Headlines

Increasing hydroxyurea dose helps to keep young sickle cell patients…

Bioengineer.org by Bioengineer.org
January 31, 2018
in Headlines, Health, Science News
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Credit: Seth Dixon / St. Jude Children's Research Hospital

St. Jude Children's Research Hospital investigators have shown that using the drug hydroxyurea to boost average fetal hemoglobin levels above 20 percent in children and teenagers with sickle cell anemia was associated with at least a two-fold reduction in hospitalization for any reason.

Results of the federally funded HUSTLE study–Hydroxyurea Study of Long-Term Effects–appeared online this week in the American Journal of Hematology.

The findings should help settle the debate about how to optimize hydroxyurea for treatment of sickle cell disease in young people. Rather than calculating a standard dose of hydroxyurea based on patients' weight, researchers used a dose-escalation approach to determine the maximum tolerated dose for each of the 230 St. Jude patients enrolled in the study.

"Our analysis showed that using this approach, hospitalizations for the average patient fell to less than one every couple of years rather than four to six annually," said lead author Jeremie Estepp, M.D., an assistant member of the St. Jude Department of Hematology. "This frees children from the fevers, pain and other symptoms of this disease and gives them and their families more chances to enjoy childhood and adolescence."

Sickle cell anemia is the most common inherited blood disorder. The disease affects about 100,000 U.S. residents and occurs most often in African-American and Hispanic individuals. They inherit a mutation that affects the hemoglobin protein that red blood cells use to ferry oxygen throughout the body. Rather than soft, pliable red blood cells that travel easily through blood vessels, the sickle cell mutation leaves patients with red blood cells that can become brittle and banana-shaped. The sickled cells clog blood vessels and lead to pain, organ damage, strokes and other symptoms and also leave patients at risk for premature death in middle age.

St. Jude pioneered the use of hydroxyurea to treat sickle cells in children. The drug is now offered to all sickle cell patients who are 9 months or older. The drug increases production of fetal hemoglobin, which functions normally in individuals with sickle cell anemia. Previously published data from HUSTLE and other studies reported that hydroxyurea was safe, reduced stroke risk and improved spleen and kidney function.

Despite hydroxyurea's proven benefits, the optimal dosing strategy for the drug has remained controversial. Also lacking has been evidence of overall improved patient outcomes if hydroxyurea is used to increase blood levels of fetal hemoglobin to more than 20 percent.

For this study, patients received a starting dose of hydroxyurea that was escalated in a stepwise manner until patients reached a predetermined maximum dose (either 35 milligrams per kilogram daily or 2,000 milligrams daily) or experienced mild neutropenia. About 2 percent of patients in this study developed transitory neutropenia, or a low level of disease-fighting white blood cells called neutrophils. More than 75 percent of patients had completed the dose escalation when study data were analyzed.

More than half the patients received a hydroxyurea starting dose of 20 milligrams per kilogram. The average dose was 27 milligrams per kilogram daily when the dose escalation process ended and ranged among patients from 13 to 35 milligrams per kilogram daily.

Pharmaceutical records suggest that patient compliance was good. Throughout the four-year study, almost 94 percent of patients had possession of their medication, which exceeded the national average. "St. Jude has invested in the clinical infrastructure, including case managers and other staff to support and follow up with families to make sure they receive recommended care, including medication," Estepp said. "These results show how patients and families benefit."

Average fetal hemoglobin levels in patients rose from 9.7 percent prior to treatment to 21.7 percent, a level that was sustained for the four years covered in this analysis. Overall, 60 percent of study patients attained fetal hemoglobin levels of more than 20 percent.

The odds of being hospitalized for pain or any reason were about doubled for sickle cell patients with fetal hemoglobin levels of 20 percent or less. The lower level was also associated with 2.6-times greater odds of hospitalization for the respiratory illness acute chest syndrome and about four-time greater odds of being hospitalized for fever.

"These results support a hydroxyurea dosing strategy designed to produce fetal hemoglobin levels that exceed 20 percent in an effort to decrease hospitalization of children with sickle cell disease," Estepp said. St. Jude researchers are now leading a multi-center trial to determine if toddlers with sickle cell disease would benefit from a similar dosing strategy or would respond better to a standard dose.

Estepp said the findings also underscore the need to improve and expand access to hydroxyurea in the U.S. and internationally.

###

Estepp is the first and corresponding author. The senior author is Jane Hankins, M.D., an associate member of the St. Jude Department of Hematology. The other authors are Guolian Kang, Chen Li and Winfred Wang, all of St. Jude; Matthew Smeltzer and Christina Abrams, both of the University of Tennessee Health Science Center, Memphis; Banu Aygun of Steven and Alexandra Cohen Children's Medical Center, New Hyde Park, New York; Russell Ware of Cincinnati Children's Hospital Medical Center; and Kerri Nottage, Janssen Research and Development, Raritan, New Jersey.

The study was funded in part by grants (HL0990941, HL127162) from the National Heart, Lung, and Blood Institute, part of the National Institutes of Health; and ALSAC, the fundraising and awareness organization of St. Jude.

St. Jude Children's Research Hospital is leading the way the world understands, treats and cures childhood cancer, sickle cell disease and other life-threatening diseases. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. St. Jude is ranked the No. 1 pediatric cancer hospital by U.S. News & World Report. Treatments developed at St. Jude have helped push the overall childhood cancer survival rate from 20 percent to 80 percent since the hospital opened more than 50 years ago. St. Jude freely shares the breakthroughs it makes, and every child saved at St. Jude means doctors and scientists worldwide can use that knowledge to save thousands more children. Families never receive a bill from St. Jude for treatment, travel, housing and food — because all a family should worry about is helping their child live. To learn more, visit stjude.org or follow St. Jude on social media at @stjuderesearch.

Media Contact

Michael Sheffield
[email protected]
901-595-0221
@StJudeResearch

http://www.stjude.org

Original Source

https://www.stjude.org/media-resources/news-releases/2017-medicine-science-news/higher-hydroxyurea-dose-improves-outcomes-for-young-sickle-cell-patients.html http://dx.doi.org/10.1002/ajh.24906

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