• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Sunday, September 7, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

How to free the trapped radicals from the carboxyl?

Bioengineer by Bioengineer
March 29, 2019
in Chemistry
Reading Time: 3 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

USTC young scientists creates a cheap and simple visible light catalytic system

IMAGE

Credit: Jie Cui, USTC News Center,

The removal of carboxyl groups and the release of alkyl radical fragments from the tight binding of carboxyl groups are one of the most interesting and promising directions in organic synthesis, especially in the field of new drug synthesis. Scientists around the world designed various catalysts try to solve this challenge. Young scientists from University of Science and Technology of China has made a big step forward developed a cheap and simple catalyst system. The research is published in Science on Mar 29th.

The free radical is versatile and controllable, representing a “Great Holy” in organic synthesis, but it is pressed by the “big mountain” of the carboxyl group. Carboxylic acid compounds makes up many familiar and important substances in our life and industrial production, such as the amino acids, acetic acid, and vinegar. The free radical fragment that is released from the carboxylic acid compounds is of great use in the industry of the materials, pharmaceuticals, and the other fields. Conventional decarboxylation processes are often carried out at elevated temperatures, which produces a large number of various unknown products, limiting their industrialization.

In recent years, the scientific community has tried to use photocatalytic reaction to achieve decarboxylation conversion, using light to excite electron transitions to generate free radical fragments for chemical bond cleavage and recombination under mild conditions. Compared with the traditional heating method, photocatalysis has many advantages, including simple operation, easy control, energy saving and environmental protection. The photocatalytic system has been successfully applied to the synthesis of various complex functional molecules, exhibiting outstanding catalytic synthesis value and the potential of industrial application.

However, most photoredox catalysts in current use are composed of precious metal complexes (such as Iridium and ruthenium) or are synthetically elaborate organic dyes with complicated structures. This makes the photocatalytic industrial system costly, complicated in process, and difficult to control. Therefore, the development of new cheap and multifunctional photocatalytic systems has become an important direction for future development. The existing major types of photocatalytic systems are complex and costly. The new catalyst has a new way to use a new mechanism to combine the cheap catalyst with the carboxyl group, push the redox reaction cycle, and easily and freely rescue the “free radicals”.

The research team of University of Science and Technology of China proposed a new concept based on visible light excitation for intermolecular charge transfer to construct a catalytic redox cycle for organic synthesis. A simple, easily available, highly efficient and non-metallic anionic composite photocatalytic system was discovered for decarboxylative reaction of carboxylic acid derivative.

The proposed catalytic system simultaneously drives a redox cycle, simplifies the photocatalytic system, and reduces the cost of the photocatalyst, breaking through the limitations of traditional heating method, and solving the problems of transition metals remaining in the synthesis of functional compounds and drugs. Using this system, redox-active esters derived from various natural and unnatural amino acids successfully triggered decarboxylativr coupling reactions with high efficiency and gram scale production, indicating the feasibility of industrialization. It is also expected to promote the scale industrialization of photocatalytic technology in the production of important functional molecules, with important synthetic chemical value and good industrial application prospects.

The reviewers highly valued this work: ” The results are interesting, and may initiate a new area of research in photoredox catalysis by introducing a tricomponent system based on a salt, a phosphine and an electron- acceptor to access redox active complexes without the need for traditional transition metal or complex dye catalysts. “, “This work gives us a very interesting concept; decarboxylative alkylation is accomplished without precious transition metals or organic dyes, which may be good news for many synthetic chemists.”

###

Media Contact
Jane FAN Qiong
[email protected]

Related Journal Article

http://dx.doi.org/10.1126/science.aav3200

Tags: Chemistry/Physics/Materials SciencesIndustrial Engineering/ChemistryPharmaceutical SciencesPharmaceutical/Combinatorial Chemistry
Share13Tweet8Share2ShareShareShare2

Related Posts

Scientists Convert Plastic Waste into High-Performance CO2 Capture Materials

Scientists Convert Plastic Waste into High-Performance CO2 Capture Materials

September 5, 2025
Decoding Orderly and Disorderly Behavior in 2D Nanomaterials: Paving the Way for AI-Driven Custom Designs

Decoding Orderly and Disorderly Behavior in 2D Nanomaterials: Paving the Way for AI-Driven Custom Designs

September 5, 2025

Physicists Develop Visible Time Crystal for the First Time

September 5, 2025

Adaptive Visible-Infrared Camouflage Enables Wide-Spectrum Radiation Control for Extreme Temperature Environments

September 5, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    150 shares
    Share 60 Tweet 38
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    116 shares
    Share 46 Tweet 29
  • First Confirmed Human Mpox Clade Ib Case China

    56 shares
    Share 22 Tweet 14
  • A Laser-Free Alternative to LASIK: Exploring New Vision Correction Methods

    47 shares
    Share 19 Tweet 12

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

ECG Insights on Stress in Scorpion Mud Turtle

Gender Variations in Microglial Stress Response Uncovered

Nitric Oxide Knockdown Affects GABA Neuron Metabolism in Rats

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.