How does a person’s ethnicity impact their risk of death?

In the UK, disparities in mortality risk factors exist between ethnic groups, with differences in overall mortality, top causes of mortality and individual mortality risk factors, according to a new study published this week in the open-access journal PLOS Global Public Health by I. King Jordan of Georgia Institute of Technology, US, and colleagues.

Despite the progress made in improving mortality rate, life expectancy, and disease survival outcomes in the last century, health disparities between various population groups persist and remain a major global health issue. Both environmental and genetic factors, with increasing evidence for interaction between environment and genetics through epigenetic mechanisms, have been cited as contributors of health disparities.

In the new study, the researchers analyzed data on 490,610 Asian, Black and White participants from the UK Biobank, a prospective study that enrolled 500,000 people in the UK aged 40 to 69 between 2006 and 2010. The UK Biobank includes data spanning physical measures, lifestyle, blood and urine biomarkers, imaging, genetic, and linked medical and death registry records.

Overall, the White ethnic group had a higher all-cause mortality rate than the Asian and Black groups. Moreover, Asian and Black females had lower risk of mortality than Asian and Black men, but that sex difference was absent among Whites. Certain causes of mortality were more common among the different ethnic groups: Asians had the highest mortality from ischemic heart disease, while Blacks had the highest mortality from COVID-19 and Whites had the highest mortality from cancers of respiratory/intrathoracic organs. In addition, some preexisting medical conditions and biomarkers showed specific associations with ethnicity and mortality. Mental health diagnoses, for instance, were a major risk factor for mortality for the Asian group, whereas parasitic diseases and C-reactive protein (CRP) serum levels were associated with higher mortality in the Black group.

“These results underscore the importance of population-specific studies that can help decompose health disparities and inform targeted interventions towards greater health equity,” the researchers concluded.

The authors add: “Despite a recent decrease in the overall burden of disease mortality, ethnic disparities in mortality persist for a number of diseases.  Our study of the United Kingdom Biobank revealed numerous blood biomarkers, environmental, and behavioral risk factors that explain ethnic disparities for all-cause mortality and disease-specific mortality for digestive system cancers, COVID-19, and coronary heart disease.”

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In your coverage please use this URL to provide access to the freely available article in PLOS Global Public Health: https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001560

Citation: Lee KK, Norris ET, Rishishwar L, Conley AB, Mariño-Ramírez L, McDonald JF, et al. (2023) Ethnic disparities in mortality and group-specific risk factors in the UK Biobank. PLOS Glob Public Health 3(2): e0001560. https://doi.org/10.1371/journal.pgph.0001560

Author Countries: USA

Funding: The work was supported by the National Institutes of Health (NIH) Distinguished Scholars Program (DSP) (1ZIAMD000016 and 1ZIAMD000018 to LMR and the Division of Intramural Research (DIR) of the National Institute on Minority Health and Health Disparities (NIMHD) at NIH), the IHRC-Georgia Tech Applied Bioinformatics Laboratory (RF383 to KKL, ETN, LR, ABC, and IKJ), and the Ovarian Cancer Institute (Atlanta), Deborah Nash Endowment, and Northside Hospital Research Foundation to JFM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.