How brains form visual maps

Maps have played an important role in scientific progress. Claudius Ptolemaeus transformed our understanding of the world with his map of Earth and Tycho Brahe our understanding of the Universe with his map of the stars. The maps of the human body from Claudius Galenus, Leonardo da Vinci, and Andreas Vesalius paved the path towards modern medicine and recent progress in human brain mapping is helping us understand better who we are. Our brains have multiple maps that are needed to plan our movements, navigate our environments, and perceive the world through our senses. The brain maps of our visual world have been studied with greatest detail and provide an opportunity to understand how other brain maps form, organize and function. Intensive research over the past decades demonstrate that maps in the primary visual area of the cerebral cortex contain an intricate representation of multiple stimulus dimensions that include spatial location, eye input, light-dark polarity, orientation, and width. For example, a capital ‘I’ in this page is mapped in the primary visual cortex as ‘location [x, y], both eyes, dark, vertical, and thin’.

Mapping our visual world in a small piece of cortex can be challenging. Remarkably, species as different as primates, carnivores, and scandentia appear to follow a common strategy and all map stimulus orientation in a pinwheel pattern. In a new paper that will be published in Nature Communications, scientists propose a theory that explains the diversity of visual maps in nature and the origin of pinwheel patterns in orientation maps. The theory proposes that map diversity emerges from variations in the sampling density of visual space. As sampling density increases during evolution, the cerebral cortex receives more neuronal inputs per visual point that are accommodated in larger cortical areas of larger brains. The larger cortical areas allow sorting the neuronal inputs in clusters that respond to the same stimulus properties: the same visual point, the same eye (left or right), and the same contrast polarity (light or dark). They also allow the inputs to combine into clusters of cortical neurons that maximize the diversity of stimuli extracted from each visual point. This maximization process creates a pinwheel pattern for stimulus orientation.

We are still far from gaining access to accurate maps of the human brain, but having a theory of brain map formation is an important first step towards reaching this milestone. The theory that the authors propose still needs to pass the test of time, but it can already explain a large number of experimental observations. It also predicts a close topographic relation among all stimulus dimensions represented in a visual map, which greatly facilitates accurate reconstructions of the multi-dimensional maps needed for future cortical implants. The work was done by Sohrab Najafian and collaborators in the laboratories of Jose Manuel Alonso at the State University of New York, College of Optometry. It will be published on April 28 at 5 am Eastern Time in Nature Communications (notice: press embargo will be lifted on this date and time).

For more information about this study, a press packet can be downloaded here: https://www.dropbox.com/sh/48lzxtzephqms82/AACYl1k1JLKuLEsgnnLNtqA0a?dl=0

Media Contact: Dawn Rigney (Vice President for Institutional Advancement, 212-938-5601, [email protected])

Abstract from the Paper: The cerebral cortex receives multiple afferents from the thalamus that segregate by stimulus modality forming cortical maps for each sense. In vision, the primary visual cortex maps the multiple dimensions of the visual stimulus in patterns that vary across species for reasons unknown. Here we introduce a general theory of cortical map formation, which proposes that map diversity emerges from species variations in the thalamic afferent density sampling sensory space. In the theory, increasing afferent sampling density enlarges the cortical domains representing the same visual point, allowing the segregation of afferents and cortical targets by multiple stimulus dimensions. We illustrate the theory with an afferent-density model that accurately replicates the maps of different species through afferent segregation followed by thalamocortical convergence pruned by visual experience. Because thalamocortical pathways use similar mechanisms for axon segregation and pruning, the theory may extend to other sensory areas of the mammalian brain.