• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Tuesday, October 28, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Cancer

Former Scripps Research Assistant Professor Honored with 2025 Nobel Prize in Physiology or Medicine

Bioengineer by Bioengineer
October 7, 2025
in Cancer
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

In a monumental stride for immunology and medical science, Shimon Sakaguchi, former assistant professor at Scripps Research, has been honored with the 2025 Nobel Prize in Physiology or Medicine. This esteemed recognition applauds Sakaguchi’s pioneering elucidation of peripheral immune tolerance, a vital immunological mechanism pivotal in preventing autoimmune diseases and explicating the multifaceted ways cancer evades immune surveillance. This groundbreaking discovery is not merely a triumph of basic science but holds profound therapeutic ramifications poised to transform clinical approaches to both autoimmune disorders and oncology.

The award is shared with Mary E. Brunkow of the Institute for Systems Biology and Fred Ramsdell of Sonoma Biotherapeutics, reflecting a collective advancement in our comprehension of immune regulation’s intricate landscape. Their joint contributions have significantly expanded the scientific community’s insight into how immune system homeostasis is maintained, highlighting the complex interplay between immune activation and suppression that safeguards the organism from self-directed damage while mounting effective defenses against pathogens and malignancies.

Sakaguchi’s critical breakthrough came in 1995 during his tenure at the Aichi Cancer Center Research Institute in Japan, shortly after his academic stint at Scripps Research from 1989 to 1991. At a time when prevailing immunological dogma posited that central tolerance was primarily enforced via deletion of autoreactive T cells in the thymus, Sakaguchi challenged this concept by identifying a novel subset of T cells characterized by the constitutive expression of the CD25 surface marker. These regulatory T cells, or Tregs, unveiled a previously unknown dimension of immune regulation operating in the periphery, distinct from central deletion processes.

The experimental foundation of this insight involved elegant mouse models genetically deficient in T cells, into which Sakaguchi reintroduced CD4+ T cells either inclusive or depleted of CD25+ populations. Remarkably, the absence of CD25+ T cells precipitated the onset of severe autoimmune pathology, whereas their presence conferred protection, conclusively demonstrating the critical role of Tregs in maintaining immune equilibrium. This functional demonstration elucidated how Tregs act centrally as “immune checkpoints,” preventing autoreactive effector cells from mounting deleterious attacks on self-antigens.

Sakaguchi’s work revolutionized understanding of the immune system’s checks and balances by showing that immune tolerance is an active, dynamic process. Tregs actively surveil and suppress the activation and

Tags: autoimmune disease preventionbasic science and clinical transformationcancer immune evasion mechanismscollaborative scientific advancementsFred Ramsdell biotherapeuticsimmune activation and suppression dynamicsimmune system homeostasis researchMary E. Brunkow contributionsNobel Prize in Physiology 2025peripheral immune tolerance discoveryShimon Sakaguchi immunology breakthroughtherapeutic implications of immunology

Share12Tweet8Share2ShareShareShare2

Related Posts

Exploring Non-Contrast Transperineal Ultrasound in Pediatric Care

October 28, 2025

Remote Radiology’s Surprising Impact on Greenhouse Gas Emissions

October 28, 2025

Study Finds Connection Between Outdoor Air Pollution and Increased Breast Cancer Risk

October 28, 2025

Checkpoint Inhibitors Plus Antiangiogenics in Liver Cancer

October 27, 2025

POPULAR NEWS

  • Sperm MicroRNAs: Crucial Mediators of Paternal Exercise Capacity Transmission

    1287 shares
    Share 514 Tweet 321
  • Stinkbug Leg Organ Hosts Symbiotic Fungi That Protect Eggs from Parasitic Wasps

    310 shares
    Share 124 Tweet 78
  • ESMO 2025: mRNA COVID Vaccines Enhance Efficacy of Cancer Immunotherapy

    198 shares
    Share 79 Tweet 50
  • New Study Suggests ALS and MS May Stem from Common Environmental Factor

    135 shares
    Share 54 Tweet 34

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Link Between Academic Success and Internalizing Disorders

N-glycosylation of IgG: A Stroke Risk Predictor

The Importance of Body Clocks for Heart Health

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 67 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.