• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Thursday, February 25, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

Designer lens helps see the big picture

Bioengineer by Bioengineer
November 20, 2019
in Chemistry
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: © 2019 KAUST


Microscopes have been at the center of many of the most important advances in biology for many centuries. Now, KAUST researchers have shown how a standard microscope can be adapted to provide even more information.

In its simplest form, microscopy creates an image of an object by measuring the intensity of light passing through it. This requires a sample that scatters and absorbs light in different ways. Many living cells, however, absorb very little visible light, meaning that there is only a small difference between light and dark regions, known as the contrast. This makes it difficult to see the finer detail.

But the light passing through the sample changes not only its intensity, but also its phase: the relative timing of the peaks in the optical wave. “Phase-contrast microscopy converts phase into larger amplitude variations and hence allows the viewing of fine, detailed transparent structures,” explains KAUST Ph.D. student Congli Wang.

Measuring the phase of light is trickier than measuring its intensity. Most phase-contrast microscopes must include a component that converts the phase change to a measurable intensity change. But this conversion is not precise; it only approximates the phase information.

Wang and his colleagues from the KAUST Visual Computing Center, under the supervision of Wolfgang Heidrich, a professor of computer science, have now developed a new method for quantitative phase and intensity imaging. Crucial to the performance of their microscope was an element known as a wavefront sensor. Wavefront sensors are custom-designed optical sensors that can encode the wavefront, or phase, information into intensity images.

The team designed an innovative high-resolution wavefront sensor, and the team members are now incorporating it into a commercial microscope to improve the performance of microscopy imaging. They then reconstructed the phase-contrast image using a computer algorithm they developed to numerically retrieved quantitative phase from an image pair: a calibration image obtained without the sample and a measurement image obtained with the sample in place.

This approach streamlines several aspects of microscopy. While other methods have achieved quantitative phase imaging in the past, they have required expensive or complicated setups, specialized light sources or a long time to generate the image. “Our method allows snapshot acquisition of high-resolution amplitude bright-field and accurate quantitative phase images via affordable simple optics, common white-light source and fast computations at video rates in real time,” says Heidrich. “It is the first time, to our knowledge, that all these advantages are combined into one technique.”

###

Media Contact
Carolyn Unck
[email protected]

Original Source

https://discovery.kaust.edu.sa/en/article/902/designer-lens-helps-see-the-big-picture

Related Journal Article

http://dx.doi.org/10.1038/s41598-019-50264-3

Tags: Algorithms/ModelsAudiovisual MediaComputer ScienceHardwareNanotechnology/MicromachinesSoftware EngineeringTechnology/Engineering/Computer Science
Share12Tweet7Share2ShareShareShare1

Related Posts

IMAGE

New shape-changing 4D materials hold promise for morphodynamic tissue engineering

February 24, 2021
IMAGE

Parker Solar Probe offers stunning view of Venus

February 24, 2021

Strengthened by chaos, new super-hard materials will stir steel together

February 24, 2021

A gene provides both protection and destruction

February 24, 2021

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    Terahertz accelerates beyond 5G towards 6G

    637 shares
    Share 255 Tweet 159
  • People living with HIV face premature heart disease and barriers to care

    81 shares
    Share 32 Tweet 20
  • Global analysis suggests COVID-19 is seasonal

    37 shares
    Share 15 Tweet 9
  • HIV: an innovative therapeutic breakthrough to optimize the immune system

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Infectious/Emerging DiseasesBiologyGeneticsEcology/EnvironmentMedicine/HealthPublic HealthTechnology/Engineering/Computer ScienceChemistry/Physics/Materials SciencescancerCell BiologyClimate ChangeMaterials

Recent Posts

  • Allergy season starts earlier each year due to climate change and pollen transport
  • A-maze-ing pheasants have two ways of navigating
  • UM scientists achieve breakthrough in culturing corals and sea anemones cells
  • CAR T-cell therapy generates lasting remissions in patients with multiple myeloma
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In