Depression increases risk of death in older adults

The article is available free with open access from the Journal of the American Geriatrics Society at https://onlinelibrary.wiley.com/doi/abs/10.1111/jgs.15731

As we age, we become more likely to experience symptoms of depression. Research shows that depression’s symptoms can be linked to a higher risk for death. Yet often, older adults’ symptoms of depression may be missed by healthcare professionals.

What’s more, symptoms of depression have been linked to heart disease and stroke in middle-aged and older adults. Researchers suggest that the depression-heart disease link could play a role in the increased risk of death among older adults who have symptoms of depression. There’s also a known link between depression and deaths from cancer and falls in older adults. These connections might contribute to an increased risk of death for older adults, researchers suggest.

Since depression symptoms change over time, it’s possible that studying those symptoms during an older adult’s doctor visits could provide more information. To learn more, a research team designed a study to investigate the role depression symptoms play in an increased risk of death over time. The team also examined the role heart disease and stroke play in the link between depression symptoms and increased risk of death. Their study was published in the Journal of the American Geriatrics Society.

The researchers used information from the Three-City Study, a French study that investigated dementia, heart disease, and stroke in people aged 65 and older during five healthcare visits the participants made over 10 years.

At the start of the study, 16 percent of 9,294 participants had a history of heart disease. Most participants were around 73 years old; 37 percent were men.

About 23 percent of participants had symptoms of depression when the study began (28 percent of women and 13 percent of men). Almost 7 percent were taking medication for their depression. At three follow-up visits, the participants were tested again for symptoms of depression.

When the participants were monitored for depression symptoms at several visits over time, symptoms of depression were linked to an increased risk for death, including death from heart disease and stroke. However, those diseases explained only a small percentage of the deaths associated with depression symptoms over time.

The researchers said their study suggested that, for older adults living with depression, preventing heart disease may not be the only factor that will help prevent or delay death. Interestingly, antidepressants were not associated with an increased risk of death in this study.

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This summary is from “Depression increases the risk of death independently from vascular events in elderly. The 3C Study.” It appears online ahead of print in the Journal of the American Geriatrics Society. The study authors are Renaud Péquignot, MD, PhD; Carole Dufouil, PhD; Karine Pérès, PhD; Sylvaine Artero,PhD; Christophe Tzourio, MD, PhD; and Jean-Philippe Empana, MD, PhD.

This research summary was developed as a public education tool by the Health in Aging Foundation. The Foundation is a national non-profit established in 1999 by the American Geriatrics Society to bring the knowledge and expertise of geriatrics healthcare professionals to the public. We are committed to ensuring that people are empowered to advocate for high-quality care by providing them with trustworthy information and reliable resources. Last year, we reached nearly 1 million people with our resources through HealthinAging.org. We also help nurture current and future geriatrics leaders by supporting opportunities to attend educational events and increase exposure to principles of excellence on caring for older adults. For more information or to support the Foundation’s work, visit http://www.HealthinAgingFoundation.org.

Included in more than 9,000 library collections around the world, the Journal of the American Geriatrics Society (JAGS) highlights emerging insights on principles of aging, approaches to older patients, geriatric syndromes, geriatric psychiatry, and geriatric diseases and disorders. First published in 1953, JAGS is now one of the oldest and most impactful publications on gerontology and geriatrics, according to ISI Journal Citation Reports®. Visitwileyonlinelibrary.com/journal/JGS for more details.

Founded in 1942, the American Geriatrics Society (AGS) is a nationwide, not-for-profit society of geriatrics healthcare professionals that has–for 75 years–worked to improve the health, independence, and quality of life of older people. Its nearly 6,000 members include geriatricians, geriatric nurses, social workers, family practitioners, physician assistants, pharmacists, and internists. The Society provides leadership to healthcare professionals, policymakers, and the public by implementing and advocating for programs in patient care, research, professional and public education, and public policy. For more information, visit AmericanGeriatrics.org.