• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Monday, August 15, 2022
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

‘cryobioprinting’ serves up towers of frozen cells

Bioengineer by Bioengineer
December 30, 2021
in Biology
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

A new technique takes bioprinting — in which an ink of cells is printed, layer by layer, to form a structure — to a whole new, and icy level. Investigators from the Zhang lab at Brigham and Women’s Hospital have developed a technology that they term “cryobioprinting,” a method that uses a bioink embedded with cells to print frozen, complex structures that can be easily stored for later use. The team introduced cryobioprinting in a paper recently published in Matter and further described how to apply the technology to muscular tissue engineering in a paper just published in Advanced Materials.

Cryobioprinting examples

Credit: Credit Y. Shrike Zhang

A new technique takes bioprinting — in which an ink of cells is printed, layer by layer, to form a structure — to a whole new, and icy level. Investigators from the Zhang lab at Brigham and Women’s Hospital have developed a technology that they term “cryobioprinting,” a method that uses a bioink embedded with cells to print frozen, complex structures that can be easily stored for later use. The team introduced cryobioprinting in a paper recently published in Matter and further described how to apply the technology to muscular tissue engineering in a paper just published in Advanced Materials.

“Cryobioprinting can give bioprinted tissue an extended shelf life. We showed up to three months of storage, but it could be much longer,” said Y. Shrike Zhang, PhD, senior author of both papers and an associate bioengineer in the Brigham’s Department of Medicine. “And the unique variation, or what we call the vertical 3D cryobioprinting technique we’ve described, may have broad application in tissue engineering, regenerative medicine, drug discovery and personalized therapeutics.”

Zhang and colleagues used a cryoprotected bioink laden with cells to print tissue constructs on a customized freezing plate. The freezing plate allowed them to precisely control and stabilize temperature during the cryobioprinting procedure. These printed structures were immediately cryopreserved in a liquid nitrogen tank for later use. The team optimized and evaluated the technique, finding that it could faithfully fabricate tissue constructs that could potentially be used as implants and tissue products.

In Advanced Materials, Zhang and co-authors report on using the cryoprotected bioink to create vertical, 3D structures that mimic complex, delicate, and anisotropic tissues found in the human body. Many tissues in the body, including muscles and neurons, are anisotropic, meaning that they have properties that are different in different directions. The structures the researchers created were also anisotropic, with microscale pores aligned in the vertical direction. As a proof-of-concept, the team constructed a muscle-tendon unit using myoblasts (cells that can give rise to muscle cells) and fibroblasts (cells that produce structural frameworks in connective tissue). The team also fabricated a muscle-microvascular unit.

The researchers note that this work represents very early technological demonstrations and will still need extensive validation and tests before use in the clinic, but the two papers represent an important step forward.

“As the field of tissue engineering is growing fast, these fabricated tissue constructs may find a plethora of applications in muscular tissue engineering and beyond,” said Zhang.

Funding: The authors acknowledge support by the Brigham Research Institute. Work was also supported by the FRQNT’s International Internship Award (279390), MITACS Globalink Research Award (IT14553), McGill’s Graduate Mobility Award, McGill’s Doctoral Internship Award, the FRQNT’s Postdoctoral Fellowship (296447), Program of China Scholarship Council (No.201807045057), the High-Level Talent Internationalization Training Program of Henan Province (No.2019004), the National Institute on Deafness and other Communication Disorders (NIDCD) of the National Institutes of Health (NIH) grant numbers R01DC005788 and R01DC014461.

Papers cited:

Ravanbakhsh H et al. “Freeform Cell-Laden Cryobioprinting for Shelf-ready Tissue Fabrication and Storage” Matter DOI: /10.1016/j.matt.2021.11.020

Luo Z et al. “Support Bath-Free Vertical Extrusion Cryo(bio)printing for Anisotropic Tissue Manufacturing” Advanced Materials DOI: 10.1002/adma.202108931

 



Journal

Matter

DOI

10.1016/j.matt.2021.11.020

Method of Research

Experimental study

Subject of Research

Cells

Article Title

Freeform Cell-Laden Cryobioprinting for Shelf-ready Tissue Fabrication and Storage

Article Publication Date

21-Dec-2021

Share12Tweet8Share2ShareShareShare2

Related Posts

Image

Weird and wonderful world of fungi shaped by evolutionary bursts, study finds

August 15, 2022
Genius dog

Gifted dogs are more playful

August 15, 2022

Scientists develop gel made from spider silk proteins for biomedical applications

August 15, 2022

DREADDful mimicry

August 15, 2022

POPULAR NEWS

  • Picture of the horse specimen.

    Ancient DNA clarifies the early history of American colonial horses

    56 shares
    Share 22 Tweet 14
  • Fatigue, headache among top lingering symptoms months after COVID

    40 shares
    Share 16 Tweet 10
  • Ill-fated ‘Into the Wild’ adventurer was victim of unfortunate timing, Oregon State study suggests

    39 shares
    Share 16 Tweet 10
  • Skin: An additional tool for the versatile elephant trunk

    38 shares
    Share 15 Tweet 10

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

UrbanizationWeaponryUrogenital SystemWeather/StormsViolence/CriminalsVirusVaccinesUniversity of WashingtonVehiclesZoology/Veterinary ScienceVirologyVaccine

Recent Posts

  • Study shows Gulf of Maine cooling for 900 years, then quickly warming since late 1800s
  • The Faraday Institution and NREL sign MOU in support of US UK joint battery research
  • Sugar chain on cell surface directs cancer cells to die
  • Colorful solar panels could make the technology more attractive
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In