A groundbreaking study led by researchers at UCLA Health has unveiled compelling evidence that bridges the long-assumed gap between cardiovascular health and cancer, revealing that specific cardiac biomarkers serve as powerful predictors of future cancer risk. This paradigm-shifting discovery challenges traditional notions that heart disease and cancer develop independently, highlighting the intricate biological interplay underpinning these two leading causes of mortality worldwide. The investigative team focused on the predictive capacity of two widely studied cardiac blood markers—high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro–B-type natriuretic peptide (NT-proBNP)—uncovering their significance beyond heart-related pathology.
Cardiac biomarkers such as hs-cTnT and NT-proBNP have historically been interpreted within the narrow realm of cardiovascular risk assessment. hs-cTnT is a sensitive indicator of myocardial injury, frequently elevated in conditions of ischemia or heart failure. NT-proBNP, by contrast, is secreted in response to cardiac wall stress and volume overload, serving as a hallmark for diagnosing and prognosticating various heart diseases. The startling revelation from the UCLA cohort adds a new dimension to these biomarkers’ utility, demonstrating their association with malignancy risk despite absence of any evident cardiovascular disease in study participants at baseline.
To explore this connection, the investigators harnessed data from the Multi-Ethnic Study of Atherosclerosis (MESA), a well-structured, prospective cohort encompassing over six thousand individuals aged 45-84. Importantly, all were initially free from cardiovascular and oncologic diagnoses, allowing for an unbiased assessment of biomarker elevation as a predictor rather than a consequence of disease. Over a median follow-up exceeding 17 years, clinical outcomes were meticulously tracked through comprehensive hospitalization records, enabling robust correlation analyses between baseline cardiac biomarker concentrations and incident cancer events.
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The findings revealed that even subtle increases in the levels of hs-cTnT and NT-proBNP bore a statistically significant relationship with heightened cancer susceptibility. When analyzed across various malignancy types, elevated levels of both markers combined portended an increased risk for colorectal cancers, a prevalent and lethal form of malignancy. Meanwhile, NT-proBNP alone displayed a unique association with lung cancer incidence, suggesting mechanistic heterogeneity in how cardiac stress biomarkers may serve as harbingers for different oncogenic processes.
Dr. Xinjiang Cai, the study’s principal investigator and a leading cardiologist at UCLA Health, expounded on the implications of this research. Traditionally, the clinical community has leveraged hs-cTnT and NT-proBNP as reliable harbingers of cardiovascular events, forming a cornerstone of preventive cardiology. However, their predictive reach now appears to transcend this domain, unveiling unexpected biological crosstalk between cardiac physiology and tumorigenesis. This insight underscores the concept of systemic pathophysiologic convergence where cardiovascular dysfunction and cancer pathobiology may share molecular pathways or be linked through chronic inflammatory states, oxidative stress, or neurohormonal dysregulation.
The study’s meticulous methodology—encompassing ethnically diverse populations and rigorous longitudinal follow-up—fortifies the credibility of these conclusions. Its observational nature does not establish causality but highlights significant associations that warrant further mechanistic exploration. The authors advocate for integrative research frameworks that unify cardiology and oncology disciplines, potentially birthing novel predictive tools and enhancing early detection endeavors for both diseases.
Moreover, the clinical ramifications of utilizing cardiac biomarkers for cancer risk stratification are profound. Since hs-cTnT and NT-proBNP assays are widely available and routinely employed in cardiovascular care, their application could be seamlessly integrated into existing screening protocols. Early identification of individuals at elevated oncologic risk could instigate tailored surveillance strategies, promoting timely interventions and potentially improving survival outcomes.
The findings also resonate with the growing appreciation of shared risk factors such as smoking, obesity, and sedentary lifestyles that underpin both cardiovascular diseases and cancers. Yet, the independent predictive power of these biomarkers beyond traditional risk parameters suggests intrinsic biological interdependencies, inviting a reevaluation of current disease models. It also prompts inquiries into whether heart-derived peptides or markers may exert systemic effects influencing carcinogenesis or whether they serve as proxies for subclinical systemic alterations.
From a translational science perspective, this study opens avenues to probe molecular mediators linking cardiac biomarker expression to tumoral environments. Investigations could explore whether elevated cardiac troponins or natriuretic peptides modulate immune surveillance, angiogenesis, or cellular proliferation pathways, thereby impacting neoplastic transformation or progression. Such insights would advance personalized medicine approaches bridging cardiology and oncology.
Co-authorship by experts spanning cardiovascular medicine, epidemiology, and population science across leading American institutions including the University of Washington, Johns Hopkins, Inova Heart and Vascular Institute, and the Lundquist Institute attests to the interdisciplinary rigor underpinning this research. Their collaborative effort epitomizes the evolving landscape of integrated clinical science aimed at tackling multifactorial chronic diseases.
Published in the prestigious Journal of the American College of Cardiology: Advances, this report heralds a significant step forward in understanding the convergence of cardiovascular and cancer risk factors. It challenges clinicians to reconsider the broader implications of cardiac biomarker readings and fuels scientific discourse about their role in systemic disease prediction frameworks.
Ultimately, the study’s insights underscore a vital public health message: the boundaries between traditionally siloed diseases are porous, guided by interwoven biological networks that demand holistic approaches for prevention and treatment. Recognizing cardiac biomarkers as dual-purpose indicators could herald a new era where cardiologic evaluations serve the dual function of cardiovascular and oncologic vigilance, improving outcomes through earlier detection and integrative care pathways.
As investigations continue, the scientific community eagerly anticipates further elucidation on the mechanistic underpinnings of these associations, the potential for clinical implementation at scale, and the ways in which this knowledge can deepen understanding of human disease in its totality. This study undeniably positions cardiac biomarkers at the frontier of novel risk stratification paradigms, promising enhanced patient care and opening doors to innovative preventive strategies in the fight against two of humanity’s deadliest adversaries.
Subject of Research: People
Article Title: Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort
News Publication Date: 16-Jun-2025
Web References:
Study in Journal of the American College of Cardiology: Advances
DOI: 10.1016/j.jacadv.2025.101884
Image Credits: UCLA Health
Keywords: Cardiovascular disorders, Cancer
Tags: biomarkers beyond heart diseasecardiac biomarkers and cancer riskcardiac troponin T role in cancer predictioncardiovascular health and cancer relationshipheart disease and malignancy connectionhs-cTnT and NT-proBNP significanceinterdisciplinary approach to health risksMulti-Ethnic Study of Atherosclerosis findingsmyocardial injury and cancer riskNT-proBNP in cancer risk assessmentpredictive capacity of cardiac markersUCLA Health cancer research
