• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, October 3, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Cancer

Cancer researchers highlight the value of digital PCR in monitoring immunotherapy effectiveness at Precision Medicine World Conference

Bioengineer by Bioengineer
January 21, 2019
in Cancer
Reading Time: 4 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Santa Clara, Calif. — January 21, 2019 — Research that demonstrates how Bio-Rad’s Droplet Digital PCR (ddPCR) technology can quickly help determine the effectiveness of immune checkpoint inhibitors and other immunotherapies will be presented by cancer researchers and medical oncologists during a Bio-Rad workshop at the Precision Medicine World Conference (PMWC) in Santa Clara, California, January 20-23.

Immunotherapies such as the checkpoint inhibitors PD-L1 and CTLA-4 and a variety of adoptive cell therapies can be effective in treating multiple types of cancer, but these immunotherapies only work with some patients. And since immunotherapy drugs can produce severe immune-related adverse events (irAEs) in patients, including dysimmune colitis and interstitial pneumonitis, and more common AEs such as headache, fatigue, chest pain, and nausea, it’s important to determine as early as possible whether the therapy is working or if it needs to be either adjusted or discontinued.

Research has shown that during the course of cancer therapy, tumor-specific genetic material, referred to as circulating tumor DNA (ctDNA), is released into a patient’s bloodstream in characteristic temporal patterns that correlate with changes in tumor burden and help in determining therapy effectiveness. Serial sampling of the patient’s blood, in a paradigm referred to as liquid biopsy, can be used to determine a patient’s response or lack of response to a particular therapy.

Because ddPCR can directly detect and quantitate tumor DNA sequences in cell-free DNA without the need for intervening library construction, as is required in next-generation sequencing, the technology can be used to rapidly, precisely, and affordably monitor absolute ctDNA concentration changes over time. In addition, given its ability to sensitively detect one cancer-associated mutation among more than 1,000 wild-type copies, ddPCR can be used to reliably determine signs of treatment failure earlier than conventional standard-of-care practices.

“Oncologists rely on biomarkers to predict in advance whether or not patients will respond to immunotherapy, but the techniques used to detect these biomarkers, such as immunohistochemistry and the evaluation of microsatellite instability and tumor mutational burden, are imperfect predictors,” said George Karlin-Neumann, PhD, Director of Scientific Affairs at Bio-Rad’s Digital Biology Group and chair of the workshop session, “Emerging Tools for Immune Response Monitoring.”

“Due to the potency of checkpoint inhibitors and other immunotherapies in treating various cancers and the potential intensity of their side effects, it’s important to determine as early as possible once treatment has begun whether or not these drugs are working,” Karlin-Neumann said.

Along with Karlin-Neumann, the workshop features panelists Jenny Lee, MD, PhD, medical oncologist and senior lecturer and clinical lead of the Precision Cancer Therapy Laboratory at Macquarie University, Sydney; Ed Schuuring, PhD, senior clinical scientist and head of the Laboratory of Molecular Pathology at the University of Groningen, the Netherlands; and Mark Raffeld, MD, Head of the Laboratory of Pathology’s Molecular Diagnostics Unit at the National Cancer Institute, Bethesda, Maryland.

During the session, panelists will discuss how ddPCR technology can be used to monitor the effectiveness of several different types of immunotherapies, including checkpoint inhibitors and cellular immunotherapies such as chimeric antigen receptor T cells (CAR-T) and tumor infiltrating lymphocytes (TIL). Data will be presented that demonstrate how ddPCR can determine within weeks how a patient is or is not responding to their immunotherapy treatment.

###

The hour-long workshop is at 11 AM Tuesday, January 21, as part of Track 2. Visit the conference website to learn more about the panelists.

Karlin-Neumann is giving a 15-minute talk discussing ddPCR technology and its applications during the Liquid Biopsy Showcase at 9:30 AM in Track 5, also on Tuesday, January 21.

To learn more about Droplet Digital PCR applications discussed at PMWC, please visit bio-rad.com/digitalPCR.

Bio-Rad, Droplet Digital PCR, and ddPCR are trademarks of Bio-Rad Laboratories, Inc. in certain jurisdictions.

About Bio-Rad

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) is a global leader in developing, manufacturing, and marketing a broad range of innovative products for the life science research and clinical diagnostic markets. With a focus on quality and customer service for over 65 years, our products advance the discovery process and improve healthcare. Our customers are university and research institutions, hospitals, public health and commercial laboratories, biotechnology, pharmaceutical, as well as applied laboratories that include food safety and environmental quality. Founded in 1952, Bio-Rad is based in Hercules, California, and has a global network of operations with more than 8,000 employees worldwide. Bio-Rad had revenues exceeding $2.1 billion in 2017. For more information, please visit http://www.bio-rad.com.

This release may be deemed to contain certain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, without limitation, statements we make regarding our development and launch of new products and our expectations regarding our products. Forward-looking statements generally can be identified by the use of forward-looking terminology such as “plan”, “believe,” “expect,” “anticipate,” “may,” “will,” “can,” “intend,” “estimate,” “continue,” or similar expressions or the negative of those terms or expressions, although not all forward-looking statements contain these words. Such statements involve risks and uncertainties, which could cause actual results to vary materially from those expressed in or indicated by the forward-looking statements. These risks and uncertainties include our ability to develop and market new or improved products, product quality and liability issues, our ability to compete effectively, and international legal and regulatory risks. For further information regarding our risks and uncertainties, please refer to the “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operation” in Bio-Rad’s public reports filed with the Securities and Exchange Commission, including our most recent Annual Report on Form 10-K and our Quarterly Report on Form 10-Q. Bio-Rad cautions you not to place undue reliance on forward-looking statements, which reflect an analysis only and speak only as of the date hereof. We disclaim any obligation to update these forward-looking statements.

Media Contact
Ken Li
[email protected]
312-532-4675

Tags: cancerClinical Trials
Share12Tweet8Share2ShareShareShare2

Related Posts

Short-Course Radiation Therapy Following Prostate Surgery Reduces Cancer Recurrence Risk

October 2, 2025

How Does Cellular Activity in Early Life Impact Cancer and Aging?

October 2, 2025

MSK’s Breakthrough Highlights from ASTRO 2025

October 2, 2025

Topical Cream Alleviates Skin Side Effects of Chemotherapy

October 2, 2025
Please login to join discussion

POPULAR NEWS

  • New Study Reveals the Science Behind Exercise and Weight Loss

    New Study Reveals the Science Behind Exercise and Weight Loss

    92 shares
    Share 37 Tweet 23
  • New Study Indicates Children’s Risk of Long COVID Could Double Following a Second Infection – The Lancet Infectious Diseases

    86 shares
    Share 34 Tweet 22
  • Physicists Develop Visible Time Crystal for the First Time

    74 shares
    Share 30 Tweet 19
  • How Donor Human Milk Storage Impacts Gut Health in Preemies

    65 shares
    Share 26 Tweet 16

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

OfGATA9 Boosts Flower Size in Sweet Osmanthus

Comprehensive Analysis of Cystic Fibrosis Treatments for Kids

Exploring Phytobiotics in Fish and Shellfish

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 60 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.