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Home NEWS Science News Biology

Biologists shed light on mystery of how microbes evolve and affect hosts

Bioengineer by Bioengineer
November 2, 2020
in Biology
Reading Time: 3 mins read
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Credit: Bill Cole

TORONTO, ON – The era of COVID-19 and the need to constantly wash one’s hands and sanitize things have brought microbes to new levels of scrutiny, particularly for their impact on an individual’s health.

While associations between microbes and their hosts, from the beneficial – think probiotics in yogurt – to the harmful – such as with viruses spread by touch – have long been known, little is known about how microbes evolve and how their evolution affects the health of their hosts.

Now, researchers at the University of Toronto and the University of Illinois at Urbana-Champaign have found that as microbes evolve and adapt to their unique hosts, they become less beneficial to hosts of other genotypes.

The findings suggest that there is probably not one universally healthy microbiome. Rather, transplanted microbes might need time to adapt to a new host before they bring benefits.

“There is this prevailing idea that the ‘survival of the fittest’ means that individuals should reap the benefits others have to offer without reciprocating,” says Megan Frederickson, associate professor in the Department of Ecology & Evolutionary Biology at the University of Toronto, and senior author of a study published in Science. “We found that over time, microbes became better adapted to their hosts through the evolution of more, rather than less, cooperation.”

The researchers, led by Frederickson and lead author Rebecca Batstone, a graduate of Frederickson’s lab and now a postdoctoral fellow at the University of Illinois at Urbana-Champaign, set out to learn what happens to microbes when paired with the same host across multiple generations of that host.

Their first step was to grow several hundred specimens of the clover-like Medicago truncatula plant in a greenhouse, giving each an initial mixture of two strains of the nitrogen-fixing bacteria Ensifer meliloti. Subsequently, they re-planted new seeds into the same pots, and repeated the process for a total of five plant generations.

After a year in the greenhouse, the researchers grew a new batch of plants, and tested the evolved microbes on them, mixing and matching different evolved microbes and different hosts. They compared how well the plants grew and how many associations they formed when they were given the original or evolved microbes, and when they were given microbes that evolved on different hosts.

Finally, the researchers sequenced the entire genomes of original and evolved microbes to see how they differed genetically.

“When we put microbes from the beginning and the end of the experiment back onto hosts, we found they did best with the same hosts they evolved on, suggesting they adapted to their local host,” said Batstone. “The derived microbes were more beneficial when they shared an evolutionary history with their host.”

The researchers say the finding suggests that evolution might favour cooperation and that scientists might be able to use experimental evolution in a laboratory setting to make microbes that provide more benefits to their hosts.

“When plants or even animals arrive in new environments, perhaps as invasive species or because they are responding to a changing climate, the microbes they encounter may be initially poor partners. But these microbes might rapidly adapt and develop a more beneficial relationship,” said Frederickson.

###

The research was supported by the Natural Sciences and Engineering Research Council of Canada and the University of Toronto.

MEDIA CONTACTS:

Megan Frederickson

Department of Ecology & Evolutionary Biology

University of Toronto

[email protected]

Rebecca Batstone

Carl R. Woese Institute for Genomic Biology

University of Illinois at Urbana-Champaign

[email protected]

Sean Bettam

Communications + Public Affairs
Faculty of Arts & Science

University of Toronto

[email protected]

Media Contact
Sean Bettam
[email protected]

Related Journal Article

http://dx.doi.org/10.1126/science.abb7222

Tags: BacteriologyBiologyEvolutionGenesMicrobiologyParasitologyPlant SciencesVirology
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