Covalent PFKL activator suppresses tumor growth
Cancer cells are often described as metabolic opportunists: they reshape the way they use nutrients so they can grow rapidly,...
Macrophage-to-myofibroblast transition-derived itaconate drives lung cancer bone metastasis via HSPA8
Lung cancer’s spread to bone is one of the most destructive stages of the disease, often causing severe pain, fractures,...
USC Engineering Students Team Up With Trojan Football
As college football season approaches, a team of students and recent alumni at the USC Viterbi School of Engineering is...
Scientists transform notoriously hated plastic into high-value lubricant
Virginia Tech researchers have developed a chemical process that turns discarded polyvinyl chloride, or PVC, into polyalphaolefin, a high-performance material...
Cold Spring Harbor, Northwell Health lead development of 150+ cancer treatment models
A decade-long international effort has produced the largest publicly available collection of patient-derived cancer organoids to date, giving researchers a...
Human brain tissue reveals how electrical stimulation changes neurons and gene activity
A team of researchers has used living human brain tissue to reveal how deep brain stimulation changes the activity of...
Cancer Dependency Map Adds Next-Generation 3D Cancer Models
For nearly a decade, the Cancer Dependency Map, known as DepMap, has helped researchers identify the genetic weaknesses that cancer...
Early NT-proBNP Versus Echocardiographic PLASE Score for Predicting PDA Surgery
A new study in Pediatric Research is examining whether a simple blood test taken early in life can predict which...
Weight Trajectories Linked to Better Head Growth in Infants Under 32 Weeks
For babies born extremely early, the first weeks outside the womb can resemble a biological balancing act. They must maintain...
EPFL’s Ursula Röthlisberger Wins Michele Parrinello Award for Computational Physical Science
Open-access scholarly publisher MDPI has named Professor Ursula Röthlisberger of the École Polytechnique Fédérale de Lausanne (EPFL) as the recipient...
Biofortified millet boosts toddler nutrition without supplement side effects
Iron deficiency affects about one in four people worldwide, with young children among those at greatest risk. In early life,...
IL-1 Signaling Strengthens Mucosal Defense Against Systemic Candida albicans Infection
A new study published in Nature Microbiology identifies signalling pathways from the interleukin-1 family as key drivers of mucosal defence...
How BRI1 Receptors Recognize Diverse Brassinosteroid Hormones
Brassinosteroids are among the most influential hormones in plant biology, yet the molecular logic that allows plants to recognize such...
Hippocampal Wiring Study Finds Graded Mossy Fiber Inputs and Targeted Inhibition
The hippocampus is often portrayed as a single memory machine, but a new connectomics study suggests that one of its...
Palmitate Drives Liver Metastasis by Suppressing Neutrophils’ Antitumour Activity
Liver metastases are among the most difficult complications of advanced cancer. Unlike many other organs, the liver is continuously exposed...
Single-nucleus analysis reveals human fat-cell subsets with distinct metabolic profiles
White fat is often portrayed as a passive storage depot, a biological warehouse where excess energy is packed away for...
Ultrasound-Guided Nasojejunal Tube Placement Reduces Malposition and Radiation in Newborns
A bedside ultrasound technique is emerging as a potential alternative to repeated X-ray checks for placing nasojejunal feeding tubes in...
Rethinking Blood Culture Timing Could Reduce NICU Antibiotic Exposure
A routine laboratory clock may hold the key to reducing unnecessary antibiotic exposure among newborns in intensive care. A new...
Northeast China Farms Lack Soil Carbon’s Maize Benefits Seen in Trials
A finding that could reshape the global conversation about climate-smart agriculture is challenging one of the field’s most appealing assumptions:...
Engineered lipid nanoparticles enable durable blood stem cell editing in humanized mice
A new lipid nanoparticle system has enabled researchers to genetically modify human haematopoietic stem and progenitor cells (HSPCs) inside humanized...