• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Sunday, October 5, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

A promising new target for urinary tract infections and kidney stones

Bioengineer by Bioengineer
September 6, 2025
in Health
Reading Time: 3 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Researchers from Tokyo Medical and Dental University (TMDU) find that the secretion of uromodulin protein into urine can be induced by treatments that may protect against urinary tract infections and kidney stones, among other diseases

Tokyo, Japan – The normal function of uromodulin, a protein that is made in the kidney and secreted into the urine, remains largely unknown. However, higher levels of uromodulin in the urine are related to lower rates of urinary tract infections and kidney stones, while higher levels of this protein in kidney cells are associated with higher rates of hypertension and chronic kidney disease. Researchers from Japan have now uncovered how uromodulin secretion into the urine can be increased by the hormone vasopressin–a finding that may have many practical applications.

In a study published recently in Hypertension, researchers from Tokyo Medical and Dental University (TMDU) revealed that vasopressin receptor stimulation leads to the short-term secretion of uromodulin into the urine in mice. They found that this occurs via the protein kinase A pathway, a common cell signaling pathway that is dependent on cyclic adenosine monophosphate (cAMP) levels, in kidney cells.

Most of our knowledge about the role of uromodulin in disease comes from genetic studies. Notably, uromodulin secretion into the urine seems to be particularly important for disease prevention, but little is known about how this secretion might occur. Researchers at Tokyo Medical and Dental University (TMDU) aimed to explore this process in more detail.

“The urinary secretion of uromodulin is associated with protection against many common diseases,” says lead author of the study Azuma Nanamatsu. “We wanted to investigate how to increase this secretion, to develop better therapies in the future.”

To do this, the researchers stimulated vasopressin receptors in mice, which has previously been reported to affect uromodulin secretion. When they saw that the treated mice had higher levels of uromodulin in the urine and lower levels in the kidney, they decided to test the effects of increased cAMP on uromodulin secretion in a kidney cell line, because vasopressin receptor stimulation leads to increased cAMP levels.

“We found that uromodulin was secreted from kidney cells when cAMP levels were increased,” explains Takayasu Mori, senior author. “This secretion only happened on the apical cell surface, which normally faces the lumen or external space in the kidney.”

The authors then found that this secretion of uromodulin could be decreased by treating cells with a protein kinase A inhibitor. Together, their findings suggest that vasopressin/cAMP/protein kinase A signaling is important for the secretion of uromodulin from kidney cells into the urine.

The findings of this study may be used to develop better therapies for diseases that are related to lower urinary uromodulin levels, such as urinary tract infections and kidney stones, as well as for those linked to higher kidney uromodulin levels, such as chronic kidney disease and hypertension.

###

The article, “Vasopressin induces urinary uromodulin secretion by activating protein kinase A,” was published in Hypertension at DOI: 10.1161/HYPERTENSIONAHA.121.17127

Media Contact
Takayasu Mori
[email protected]

Original Source

https://www.tmd.ac.jp/english/press-release/20210426-1/

Related Journal Article

http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.17127

Tags: Cell BiologyInternal MedicineMedicine/HealthUrogenital System
Share13Tweet8Share2ShareShareShare2

Related Posts

Healthcare Workers’ Views on HIV and Non-Communicable Care

October 5, 2025

Supporting Caregivers of COPD Patients: Key Insights

October 5, 2025

Evaluating Mid-Upper Arm Circumference for Child Thinness

October 5, 2025

GDI-PMNet Enables Joint Prediction of Glioma Markers

October 5, 2025
Please login to join discussion

POPULAR NEWS

  • New Study Reveals the Science Behind Exercise and Weight Loss

    New Study Reveals the Science Behind Exercise and Weight Loss

    94 shares
    Share 38 Tweet 24
  • New Study Indicates Children’s Risk of Long COVID Could Double Following a Second Infection – The Lancet Infectious Diseases

    92 shares
    Share 37 Tweet 23
  • Physicists Develop Visible Time Crystal for the First Time

    75 shares
    Share 30 Tweet 19
  • New Insights Suggest ALS May Be an Autoimmune Disease

    70 shares
    Share 28 Tweet 18

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Exploring Multimodal Language Models in Chemistry Research

Healthcare Workers’ Views on HIV and Non-Communicable Care

Supporting Caregivers of COPD Patients: Key Insights

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 62 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.