• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Saturday, February 27, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

A novel gene discovery associated with a development disorder of pituitary origin

Bioengineer by Bioengineer
February 22, 2021
in Biology
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Noora Kaikkonen

The pituitary gland is a pea-sized endocrine gland composed of two structurally and functionally separate parts known as anterior and posterior lobes. The pituitary gland’s anterior lobe secretes six hormones essential to growth, reproduction, and other basic physiological functions. Abnormal development of the pituitary gland, or hypopituitarism, can cause mild or complete deficiency of one or more pituitary hormones, which manifests as highly varying symptoms. Tumours mainly cause hypopituitarism in humans, but a congenital factor can also be associated with the disorder.

The POU1F1 gene regulates the development of the anterior pituitary lobe, and disruption to its function results in hormonal changes, evidenced in affected dogs as dwarfism and coat abnormalities. A gene test developed based on the findings supports diagnostics and a breeding programme to eradicate the disease from the breed.

“Roughly 30 genes have been associated with inherited hypopituitarism in humans, many of which are regulator genes, which affect the development of the pituitary gland. In addition to humans, impaired pituitary function occurs in mice and dogs. In German Shepherds, hypopituitarism has previously been associated with the LHX3 gene, while in the case of Karelian Bear Dogs, the disease was described in Denmark already 45 years ago. Now, we have identified a related cause in the POU1F1 gene. This is only the second new canine model for human pituitary disease, making it quite significant,” says Professor Hannes Lohi.

Samples for the study were collected from Finnish and Swedish symptomatic and asymptomatic Karelian Bear Dogs.

“We managed to get samples from a total of eight sick puppies from five different litters. The puppies were as much as 20 centimetres smaller than normal, with many of them also having a puppy-like coat or substantial hair loss. Typical of the disease, their symptoms were varied. A handful of carriers of the POU1F1 variant were also found in Lapponian Herders in an analysis encompassing more than 8,000 dogs,” says Kaisa Kyöstilä, PhD, the first author of the article.

The study confirmed that the disease is inherited recessively, meaning that the affected dogs inherit the gene variant from both parents. Among Karelian Bear Dogs, only 8% of the breed carries the defect, and carriers do not develop the disease. The gene test based on the research finding can be used to identify carriers, avoid carrier-carrier combinations in breeding and eradicate this severe disease from the breed altogether.

The latest POU1F1 gene discovery is already the third disease gene described in Karelian Bear Dogs. The research group has previously described gene finds associated with dwarfism (link in Finnish only) and hypophosphatasia.

###

The study is part of Professor Hannes Lohi’s gene research programme at the Faculties of Veterinary Medicine and Medicine, University of Helsinki, and the Folkhälsan Research Center. This study was partially supported by the Canine Health Research Fund, the Jane and Aatos Erkko Foundation, the Academy of Finland, HiLIFE – the Helsinki Institute of Life Science and Wisdom Health.

Media Contact
Hannes Lohi
[email protected]

Original Source

https://www.helsinki.fi/en/news/life-science-news/a-novel-gene-discovery-associated-with-a-development-disorder-of-pituitary-origin

Related Journal Article

http://dx.doi.org/10.1007/s00439-021-02259-2

Tags: BiologyDiagnosticsEndocrinologyGenesGenetics
Share12Tweet8Share2ShareShareShare2

Related Posts

IMAGE

Predicts the onset of Alzheimer’s Disease (AD) using deep learning-based Splice-AI

February 27, 2021
IMAGE

Cerium sidelines silver to make drug precursor

February 26, 2021

Agents of food-borne zoonoses confirmed to parasitise newly-recorded in Thailand snails

February 26, 2021

Dinosaur species: ‘Everyone’s unique’

February 26, 2021

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    Terahertz accelerates beyond 5G towards 6G

    638 shares
    Share 255 Tweet 160
  • People living with HIV face premature heart disease and barriers to care

    82 shares
    Share 33 Tweet 21
  • Global analysis suggests COVID-19 is seasonal

    38 shares
    Share 15 Tweet 10
  • HIV: an innovative therapeutic breakthrough to optimize the immune system

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Technology/Engineering/Computer ScienceMedicine/HealthcancerInfectious/Emerging DiseasesEcology/EnvironmentMaterialsCell BiologyClimate ChangeBiologyGeneticsPublic HealthChemistry/Physics/Materials Sciences

Recent Posts

  • Predicts the onset of Alzheimer’s Disease (AD) using deep learning-based Splice-AI
  • When foams collapse (and when they don’t)
  • UTA researcher explores effects of trauma at the cellular, tissue levels of the brain
  • Picture books can boost physical activity for youth with autism
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In