New minimally invasive treatments offered in NHCS offer hope for patients with severe heart valve disease

Singapore, 11 May 2022 – National Heart Centre Singapore (NHCS) now offers two new procedures – TricValve® and TriClipTM – bringing a comprehensive suite of treatment options, ranging from medication therapies, minimally invasive (percutaneous or transcatheter) procedures, and surgical treatments to repair or replace the damaged valve, to patients with severe tricuspid valve problems. Being the early adopter for advanced valve therapies, NHCS was the first in Asia to introduce Transcatheter Aortic Valve Implantation (TAVI), also known as Percutaneous Aortic Valve Replacement (PAVR) in 2009, and also to perform minimally invasive heart valve repair using the MitraClip system in 2011.

In the past, treatment of severe tricuspid regurgitation was limited to medications to alleviate symptoms, and surgery to repair or replace the valve. For some patients, operative risk was high and the condition was left largely undertreated. Now, with the advancement and availability of less invasive transcatheter valve therapies, such as TricValve® and TriClipTM, selected patients who are unsuitable for open heart surgery might be able to get their condition treated. Although these are relatively new procedures for which long-term data on outcomes are still being studied, they are additional options for patients with significant symptoms who are deemed unsuitable for surgery.

What is tricuspid regurgitation?
Tricuspid regurgitation (also known as leaky heart valve) occurs when the valve between the two right heart chambers (atrium and ventricle) does not close properly, causing blood to leak backwards. When the regurgitation becomes severe, it can lead to congestion in various organs such as the liver and the kidney, and affect their function. Severe tricuspid regurgitation has been shown to be associated with significant mortality and morbidity^.1

New procedures to treat severe tricuspid regurgitation:

1. TricValve® Transcatheter Bicaval Valves System: The procedure involves inserting 2 bioprosthetic (tissue) valves known as the TricValve® into the large veins close to the heart, without the need to remove the defective tricuspid valve. NHCS has successfully performed three cases to-date and is the first centre in Singapore to offer this treatment.
2. TriClipTM Transcatheter Tricuspid Valve Repair System: The TriClipTM procedure builds upon the successful MitraClip system. It serves to repair the leaky tricuspid valves by delivering a clip system to the heart through the femoral vein in the leg, and clipping a portion of the leaflets of the tricuspid valve to reduce backflow of blood. NHCS has successfully performed the first case in Southeast Asia.

Hope for patients with severe tricuspid regurgitation
In 2020, when 52-year old Mr Tan experienced shortness of breath, leg swelling and abdominal bloatedness, little did he know, he had severe tricuspid regurgitation. As Mr Tan has an underlying condition known as Marfan syndrome which affects the aorta and had undergone several surgeries, he is considered high risk for tricuspid valve surgery. An earlier attempt to treat the tricuspid regurgitation could not improve his condition. Fortunately, the availability of TricValve® provided him an alternative treatment, enabling him to recover faster and improve his quality of life.

“We strive to constantly look at advancing treatments to improve patient care and bring better health outcomes. The introduction of these new transcatheter valve therapies provide viable treatments for severe tricuspid regurgitation that will help patients to alleviate their symptoms, shorten hospital stay and recovery time, and more importantly, improve their quality of life,” shared Associate Professor Yeo Khung Keong, Deputy Chief Executive Officer (Data Science & Innovation) and Senior Consultant, Department of Cardiology, NHCS and the lead physician for TricValve® and TriClipTM procedures. “During the TricValve® procedure, two bioprosthetic valves are inserted through the blood vessel of the patient’s leg and placed in the venous system close to the right heart chambers. The valves then self-expand in place and work to reduce the backflow of blood and pressure on the other organs in the body. There is no need to remove or repair the original tricuspid valve, allowing for future interventions if required,” explained Dr Wong Ningyan, Consultant, Department of Cardiology. Prof Yeo adds, “The TriClipTM system, on the other hand, works to repair the leaky tricuspid valve. The clip system is inserted into the femoral vein in the leg and delivered to the heart to clip the leaflets of the damaged valve together, effectively reducing backflow of blood and relieving patient’s symptoms.” 

—————————————————————————————————————————
_{1. Yan Topilsky, MD,* Vuyisile T. Nkomo, MD,y Ori Vatury, MD,y Hector I. Michelena, MD,y Thierry Letourneau, MD,y Rakesh M. Suri, MD, DPHIL,z Sorin Pislaru, MD,y Soon Park, MD,z Douglas W. Mahoney, MSC,x Simon Biner, MD,* Maurice Enriquez-Sarano, MDy. Clinical Outcome of Isolated Tricuspid Regurgitation (http://dx.doi.org/10.1016/j.jcmg.2014.07.018)}

======================== END =======================
Media Contact
Ms Elaine Loh
Corporate Development
National Heart Centre Singapore
Tel: (65) 6704 2387
Email: [email protected]

Ms Belinda Lim
Corporate Development
National Heart Centre Singapore
Tel: (65) 6704 2386
Email: [email protected]

About the National Heart Centre Singapore
The National Heart Centre Singapore (NHCS) is a 185-bed national and regional referral centre for cardiovascular diseases. NHCS provides a one-stop comprehensive cardiac care ranging from preventive, diagnostic, therapeutic to rehabilitative services. It is also the only heart and lung transplantation centre in Singapore. Each year, NHCS handles over 120,000 outpatient consultations, 9,000 interventional and surgical procedures and 10,000 inpatients. Its clinical outcomes for heart attack treatment, balloon angioplasty with stenting and coronary bypass surgery have been shown to be equivalent to international benchmarks. Established in 1998, NHCS is the pioneer in cardiovascular care in Singapore. For more information, please visit www.nhcs.com.sg.