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Home NEWS Science News Health

Breast cancer patients with government insurance at higher risk of death

Bioengineer by Bioengineer
December 13, 2019
in Health
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Medicare and Medicaid patients with breast cancer also had an increased likelihood of stopping their clinical trial treatment early, same study found

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A retrospective study of nearly 9800 women with breast cancer who participated in randomized clinical trials was presented today at the 2019 San Antonio Breast Cancer Symposium. The study found that women with government insurance (Medicaid or Medicare) were much less likely to participate in a clinical trial compared to their privately insured counterparts. The few women with government insurance who did participate in the trials were more likely to stop treatment early and had lower survival. The study was conducted by researchers in the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) with funding from the National Cancer Institute, part of the National Institutes of Health.

“Having insurance in and of itself was not enough to ensure access to a clinical trial or a good clinical outcome,” said lead researcher Samilia Obeng-Gyasi, MD, a breast surgical oncologist at The Ohio State University who studies social determinants of cancer care.

Dr. Obeng-Gyasi and colleagues looked at data from women who participated in two large ECOG-ACRIN trials testing chemotherapy treatments. Study E1199 enrolled participants from 1999 to 2002 and study E5103 enrolled participants between 2007 and 2011. In the current analysis, Dr. Obeng-Gyasi and colleagues evaluated each participant’s insurance coverage and neighborhood socioeconomic status at the time they entered the trial, to determine if either status affected the women’s clinical outcomes later on.

Insurance status was either private, government (Medicaid, Medicare), or self-pay. Only about 13% of participants in each of the two trials had government insurance. The majority of patients had private insurance (85.6% in E1199 and 82% in E5103).

Patients with government insurance were less likely to complete treatment compared to their privately insured counterparts. One out of every four government insured patients did not complete treatment in E1199 versus one out of every seven privately insured women. In E5103, approximately one out of every two government insured patients did not complete therapy compared to one out of every three privately insured patients. Completion of the trial and survival outcomes were each controlled for disease severity, age, and other patient characteristics that could influence the participant’s outcomes.

The government insured patients also had a higher risk of dying compared to their privately insured counterparts. In E1199, the risk of death increased by one half. For those in E5103, the risk increased by one-third.

The researchers determined the neighborhood socioeconomic status of each participant by linking their zip code to county-level data on occupation, income, poverty, wealth, education, and crowding.

There was no association between neighborhood socioeconomic status and trial completion or survival.

“Insurance appears to be a powerful determinant of clinical trial outcomes,” said Dr. Obeng-Gyasi. “With continued changes to insurance at the federal and state levels, physicians and policy-makers would benefit from having more data such as what we produced in our study. Right now, most clinical trials do not collect data on social determinants of health. If they did, the information could lead us to better understand the interaction of insurance status and many other factors on the clinical outcomes of clinical trial participants.”

Abstract PD10-09: Impact of insurance and socioeconomic status on clinical outcomes in therapeutic clinical trials for breast cancer. Category: Disparities and Barriers to Care. First author: Samilia Obeng-Gyasi. PD10 Spotlight Session: Toxicity, Tolerability & Cost (Friday, December 13, 7:00 AM.)

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About the ECOG-ACRIN Cancer Research Group

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) is a membership-based scientific organization that designs and conducts cancer research involving adults who have or are at risk of developing cancer. ECOG-ACRIN comprises nearly 1100 member institutions in the United States and around the world. Approximately 12,000 physicians, translational scientists, and associated research professionals from the member institutions are involved in Group research, which is organized into three scientific programs: Cancer Control and Outcomes, Therapeutic Studies, and Biomarker Sciences. ECOG-ACRIN is supported primarily through National Cancer Institute research grant funding, but also receives funding from private sector organizations through philanthropy and collaborations. Its headquarters are in Philadelphia, Pa.

Media Contact
Diane M Dragaud
[email protected]
215-789-3631

Original Source

https://ecog-acrin.org/news-and-info/press-releases/breast-cancer-patients-with-government-insurance-at-higher-risk-of-death

Tags: Breast CancercancerClinical TrialsHealth Care Systems/ServicesHealth ProfessionalsMedicine/HealthPublic HealthSocioeconomics
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