• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, August 22, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

IDIBELL — ICO researchers set new bases to develop therapies against colorectal cancer

Bioengineer by Bioengineer
April 17, 2019
in Health
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

The discovery is based on targeting the tissue surrounding the tumor, instead of the tumor directly

IMAGE

Credit: Gemma Fornons

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ProCURE program), led by Dr. David G. Molleví with Dr. Natalia Guillén Díaz-Maroto as the first author, published in Clinical Cancer Research the bases for new therapies against colorectal cancer. The study was carried out within Oncobell, IDIBELL’s research program focused on experimental therapies and molecular mechanisms in cancer.

“We have found that if we inactivate two proteins, called TAK1 and TGFBR1, which are involved in cellular signaling in normal tissue surrounding tumors, tumoral cells are more sensitive to chemotherapy and their metastatic capacity is reduced”, comments Dr. Molleví.

In a developed tumor we find different cell types. On the one hand, there are the cancerous cells, and on the other hand, there are “normal” cells, which are generically called stroma. Amongst these cells, the most common type are the fibroblasts, which provide support as if it were a scaffold. Fibroblasts supply, through the previously mentioned proteins (TAK1 and TGFBR1), molecules and factors that nourish the tumor and make it “invisible” to chemotherapy treatments.

One of the many existing research lines against cancer tries to alter the interaction between stroma and tumor, so that the tumor’s development is impaired, rendering it vulnerable. This way, tumors can be treated with chemotherapy with a lesser probability of resurgence.

“This finding provides the rationale to create new therapies against colorectal cancer, especially in the most abundant tumor subgroup in fibroblasts” adds Molleví.

Now, it will be just a matter of time to see how long it will take for new therapies to be developed based on the study results.

###

Media Contact
Gemma Fornons
[email protected]

Original Source

http://clincancerres.aacrjournals.org/content/early/2019/04/12/1078-0432.CCR-18-3957.abstract

Related Journal Article

http://dx.doi.org/10.1158/1078-0432.CCR-18-3957

Tags: cancerCell BiologyGastroenterologyGeneticsMedicine/Health
Share12Tweet8Share2ShareShareShare2

Related Posts

CrAAVe-seq reveals key neuronal genes in vivo

CrAAVe-seq reveals key neuronal genes in vivo

August 22, 2025
blank

Blocking Spermine Metabolism Boosts Pancreatic Cancer Immunity

August 22, 2025

Vaginal Estrogen Tablets Show Safety Potential for Postmenopausal Stroke Survivors

August 22, 2025

AI Deciphers Brain Network Differences in Tremors

August 22, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Molecules in Focus: Capturing the Timeless Dance of Particles

    141 shares
    Share 56 Tweet 35
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    114 shares
    Share 46 Tweet 29
  • Neuropsychiatric Risks Linked to COVID-19 Revealed

    81 shares
    Share 32 Tweet 20
  • Modified DASH Diet Reduces Blood Sugar Levels in Adults with Type 2 Diabetes, Clinical Trial Finds

    60 shares
    Share 24 Tweet 15

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Scientists Unveil Breakthrough Technique for Large-Scale Metabolite Analysis in Biological Samples

Metabolic Profiling Reveals RCC Drug Response

Electrochemical Hybrid Flow Cell Captures CO2 Directly

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.