• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Saturday, October 25, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

3D imaging reveals neural ‘vicious cycle’ in fatty liver disease

Bioengineer by Bioengineer
July 22, 2021
in Health
Reading Time: 2 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Adori et al., Science Advances, July 2021.

With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is conducted in mice and human liver tissue, shows that the degeneration of nerves is correlated with the severity of liver pathology. The results are being published in the journal Science Advances.

Non-alcoholic fatty liver disease is the most common hepatic disorder, with prevalence around 25 percent globally. Approximately one third of all fatty liver cases will develop to steatohepatitis, which is a severe disease seriously affecting the entire metabolism.

In the current paper, researchers explore the nervous system in fatty liver using volume immuno-imaging and light sheet microscopy ? a novel imaging technique, which altogether offer large-scale 3D visualization with cellular resolution. According to the study, this technology can reveal even early, minor or hidden structural impairments of the liver.

“Now we know that nerves in the liver have multiple subtle regulatory roles” says Csaba Adori, researcher at the Department of Neuroscience, who led the study. “Their role, however, may be more essential during the fight-or-flight response or when subjected to metabolic challenges. Degeneration of liver sympathetic nerves and abnormal operation of the remaining nerve fibres in the fatty liver could compromise all these functions, which may contribute to further aggravation of the disease, as part of a vicious cycle.”

According to the study, alterations in the liver innervation occurs already in early stages of fatty liver disease. With progression to the more severe steatohepatitis, these impairments turn to a pronounced degeneration of the nerves. The nerve pathology is also similar in mouse model of fatty liver and in human fatty liver samples. The research team now hopes that the study results will open the door for new therapeutic approaches in the treatment of steatohepatitis and portal hypertension, by targeting the liver sympathetic nervous system.

###

The study was supported by the Knut and Alice Wallenberg Foundation, the Swedish Research Council, the Sven Mattsson’s Foundation, the Åhlén-Foundation and the NovoNordisk Foundation. Researchers from SciLifeLab, Karolinska University Hospital, and several universities in Sweden, Slovakia and USA also contributed to the study.

Publication: ‘Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging’, C. Adori, T. Daraio, R. Kuiper, S. Barde, L. Horvathova, T. Yoshitake, R. Ihnatko, I. Valladolid-Acebes, P. Vercruysse, A. M. Wellendorf, R. Gramignoli, B. Bozoky, J. Kehr, E. Theodorsson, J. A. Cancelas, B. Mravec, C. Jorns, E. Ellis, J. Mulder, M. Uhlén, C. Bark, T. Hökfelt, Science Advances, online 21 July 2021, doi: 10.1126/sciadv.abg5733

More about Karolinska Institutet — a medical university: ki.se/en

Media Contact
KI Press Office
[email protected]

Original Source

https://news.ki.se/3d-imaging-reveals-neural-vicious-cycle-in-fatty-liver-disease

Related Journal Article

http://dx.doi.org/10.1126/sciadv.abg5733

Tags: LiverMedicine/HealthMetabolism/Metabolic Diseasesneurobiology
Share13Tweet8Share2ShareShareShare2

Related Posts

Glymphatic Flow Dysfunction Linked to Parkinson’s Disease

October 25, 2025

Night Shift Impact on Nurses’ Heart Rate Variability

October 25, 2025

Understanding Metabolic Dysfunction in Indian Liver Disease

October 25, 2025

Fatty Acid Disorder Screening: Insights from Southeastern China

October 25, 2025
Please login to join discussion

POPULAR NEWS

  • Sperm MicroRNAs: Crucial Mediators of Paternal Exercise Capacity Transmission

    1281 shares
    Share 512 Tweet 320
  • Stinkbug Leg Organ Hosts Symbiotic Fungi That Protect Eggs from Parasitic Wasps

    309 shares
    Share 124 Tweet 77
  • ESMO 2025: mRNA COVID Vaccines Enhance Efficacy of Cancer Immunotherapy

    192 shares
    Share 77 Tweet 48
  • New Study Suggests ALS and MS May Stem from Common Environmental Factor

    133 shares
    Share 53 Tweet 33

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Glymphatic Flow Dysfunction Linked to Parkinson’s Disease

Night Shift Impact on Nurses’ Heart Rate Variability

Assessing Quality of Life After Neoadjuvant Therapy

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 67 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.