• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, October 3, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Weill Cornell Medicine receives grant from NIH’s Common Fund Program

Bioengineer by Bioengineer
May 11, 2023
in Health
Reading Time: 2 mins read
0
Weill Cornell Medicine Receives Grant from NIH’s Common Fund Program
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Weill Cornell Medicine has received a grant from the National Institutes of Health (NIH) as part of a new $140 million Common Fund program to study somatic mosaicism, a phenomenon in which organs and tissues develop significant genetic differences across their cell populations.

Weill Cornell Medicine Receives Grant from NIH’s Common Fund Program

Credit: Rene Perez

Weill Cornell Medicine has received a grant from the National Institutes of Health (NIH) as part of a new $140 million Common Fund program to study somatic mosaicism, a phenomenon in which organs and tissues develop significant genetic differences across their cell populations.

The two-year, $834,000 grant, with a possible three-year extension, awarded under the Somatic Mosaicism across Human Tissues (SMaHT) Network program, will fund research led by Dr. Dan Landau, an associate professor of medicine in the division of hematology and medical oncology at Weill Cornell Medicine and a core faculty member of the New York Genome Center (NYGC). Dr. Landau and co-PI Dr. Rahul Satija, a core faculty member of the NYGC and an associate professor of biology at New York University, will develop tools for studying somatic mosaicism in detail using a “single-cell multi-omics” approach. The new tools will allow the investigators to identify DNA sequences, gene expression levels and other layers of information in individual cells, to better understand how somatic mosaicism arises and develops.

Somatic mosaicism arises when a mutation in one or more genes gives a cell a small growth or “fitness” advantage; the cell then proliferates to form a higher-growth family or “clonal outgrowth” of cells containing the new mutation. As humans and other animals age, they acquire more and more of these genetically distinct outgrowths—which seem to function normally or almost-normally, though they represent the first step on the path to cancer. Clonal outgrowths are also suspected of playing a role in many other disorders, but their full impact on human health is unknown.

“Our overarching goal is to be able to make detailed comparisons between wild-type and mutant cells to comprehensively identify the underpinnings of fitness advantage in clonal outgrowths,” said Dr. Landau, who is also a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.

Research in this area has been very challenging because, typically, only the cell-by-cell sequencing of DNA in a tissue sample can distinguish clonal outgrowth cells from normal cells. Dr. Landau and his laboratory have helped pioneer the use of single-cell sequencing tools and have developed methods to extend single-cell analysis beyond DNA-sequencing, to also record gene activity patterns, protein levels, and methylations and other “epigenetic” markers that regulate gene activity—all with the high throughput necessary for thorough examinations of human tissue samples.

Overall, the SMaHT network will establish multiple critical research centers and technology development efforts, to support the characterization of somatic mosaicism in different cell types, tissues, and life stages.

Dr. Landau’s Somatic Mosaicism across Human Tissues (SMaHT) Network research is supported by NIH grant 1 UG3 NS132139-01.



Share12Tweet8Share2ShareShareShare2

Related Posts

Marcus Kinetics Control Singlet, Triplet Oxygen Evolution

October 3, 2025

Physiologically Relevant Intermediate State of Potassium Channel

October 3, 2025

Identifying Healthcare Waste Behavior: An Australian Case Study

October 3, 2025

Capsaicin, Nicotine Ease MPTP Olfactory Dysfunction via Neuroinflammation Suppression

October 3, 2025

POPULAR NEWS

  • New Study Reveals the Science Behind Exercise and Weight Loss

    New Study Reveals the Science Behind Exercise and Weight Loss

    92 shares
    Share 37 Tweet 23
  • New Study Indicates Children’s Risk of Long COVID Could Double Following a Second Infection – The Lancet Infectious Diseases

    86 shares
    Share 34 Tweet 22
  • Physicists Develop Visible Time Crystal for the First Time

    75 shares
    Share 30 Tweet 19
  • How Donor Human Milk Storage Impacts Gut Health in Preemies

    65 shares
    Share 26 Tweet 16

About

BIOENGINEER.ORG

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Marcus Kinetics Control Singlet, Triplet Oxygen Evolution

Proteoform Discovery via Top-Down Mass Spectrometry

Physiologically Relevant Intermediate State of Potassium Channel

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 60 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.