A groundbreaking study from researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University, in collaboration with Harvard T.H. Chan School of Public Health, sheds new light on the profound impact of carbohydrate quality and dietary fiber intake in midlife on healthy aging. Published in the prestigious journal JAMA Network Open on May 16, 2025, this extensive longitudinal research follows more than 47,000 women over three decades to unravel how midlife nutrition influences physical, cognitive, and emotional health in their later years.
The research team, led by Dr. Andres Ardisson Korat, sought to move beyond conventional approaches that focus on immediate metabolic responses to carbohydrates, such as glycemic control or weight management. Instead, they scrutinized the long-term implications of carbohydrate intake on aging outcomes up to 30 years later. “Our goal was to understand not just the short-term effects of dietary carbohydrates but their role in sustaining health and function into advanced age,” noted Korat, emphasizing the critical importance of carbohydrate quality rather than quantity.
Utilizing data from the continually updated Nurses’ Health Study questionnaires collected approximately every four years between 1984 and 2016, the researchers conducted a rigorous diet-cognition-health correlation analysis. Study participants were women aged 70 to 93 in 2016, with detailed midlife dietary assessments sourced from validated food-frequency questionnaires. These tools accounted for a variety of carbohydrate subtypes, including total carbohydrates, refined versus unrefined sources, specific contributions from whole grains, fruits, vegetables, legumes, and measures of dietary fiber, glycemic index, and glycemic load.
Central to the study’s design was the innovative definition of “healthy aging,” which goes beyond the absence of disease. It encompassed a stringent criterion combining freedom from 11 major chronic illnesses, maintained cognitive and physical function, and favorable mental health status—all self-reported through consistently administered questionnaires. Out of the total cohort, 3,706 women met this comprehensive standard, enabling the researchers to identify dietary patterns linked to their favorable aging trajectories.
The findings were striking. Higher intakes of total carbohydrates and particularly high-quality carbohydrates—those derived from whole grains, fruits, vegetables, and legumes—along with increased dietary fiber in midlife, correlated with a 6% to 37% greater likelihood of achieving healthy aging. This association spanned multiple domains including physical functioning and cognitive health, suggesting that the benefits of complex carbohydrates and fiber extend well beyond cardiovascular and metabolic parameters traditionally studied.
By contrast, diets rich in refined carbohydrates, characterized by added sugars, refined grains, and starchy vegetables such as potatoes, were independently associated with significantly diminished odds of healthy aging—roughly 13% lower likelihood. These data underscore the negative ramifications of refined carbohydrates, which often promote systemic inflammation, insulin resistance, and nutrient dilution, thus accelerating chronic disease risk and functional decline in the elderly.
The study further enriches the mounting body of evidence supporting the health-promoting roles of fruits, vegetables, whole grains, and legumes. While previous research has linked these foods to reduced incidences of chronic conditions like type 2 diabetes, cardiovascular disease, and some cancers, this investigation is among the first to explicitly demonstrate their protective effect on cognitive and physical resilience during aging. Senior author Dr. Qi Sun highlighted this multidimensional impact, remarking on the convergence of nutrition science, epidemiology, and gerontology informing preventive strategies aimed at aging populations.
Despite its considerable scale and detailed analysis, the study authors caution that the cohort primarily comprised white, female health professionals, which may limit the generalizability of results across more diverse racial and socio-economic populations. They call for future research to replicate these findings in heterogeneous groups and to delve deeper into the biological mechanisms by which dietary fiber and high-quality carbohydrates may modulate aging processes.
Emerging hypotheses suggest that dietary fiber’s benefits on the gut microbiome, systemic inflammation, and metabolic homeostasis could be key pathways linking nutrition to extended healthspan. Likewise, the phytonutrients and micronutrients abundant in unrefined carbohydrates may exert neuroprotective effects and support vascular integrity, which are vital to cognitive preservation. Disentangling these complex interactions represents an exciting frontier for nutrition science and healthy aging research.
Moreover, this study complements a growing recognition that the quality of macronutrient intake in midlife — rather than merely the quantity—can have profound influences on quality of life decades later. The findings advocate for public health initiatives aimed at increasing dietary fiber and unrefined carbohydrate consumption while reducing added sugars and refined grains, thereby fostering not just longevity but true healthspan.
As Dr. Ardisson Korat eloquently summarized, “Understanding how midlife diet shapes later-life well-being empowers individuals and healthcare providers to make informed dietary choices. Our research offers hope that nutritional strategies can enhance life quality, preserve function, and support mental health in an aging society.”
Supported by grants from the U.S. Department of Agriculture’s Agricultural Research Service and multiple awards from the National Institutes of Health, this study exemplifies the value of long-term epidemiological data and interdisciplinary collaboration in illuminating how diet shapes human aging. It opens new avenues for both clinical practice and public policy to prioritize carbohydrate quality in nutritional guidelines for aging populations.
In an era of global demographic shifts leading to increased longevity but often accompanied by rising chronic disease burdens, these insights remind us that the foods we consume in midlife lay the foundation for healthier, more vibrant years ahead. With continued research and translation into actionable dietary recommendations, the path to healthier aging becomes a tangible public health goal.
Subject of Research: The impact of midlife carbohydrate quality and dietary fiber intake on healthy aging outcomes in older women.
Article Title: Intakes of total and high-quality carbohydrates and dietary fiber in midlife are associated with healthy aging in older women.
News Publication Date: 16-May-2025
Web References:
Jean Mayer USDA Human Nutrition Research Center on Aging
DOI: 10.1001/jamanetworkopen.2025.11056
Image Credits: Alonso Nichols/Tufts University
Keywords: Nutrition, Older adults, Diets
Tags: cognitive health in older womendietary fiber intake and agingemotional well-being and nutritionhealthy aging and carbohydrate qualityimpact of dietary carbohydrates on longevityJAMA Network Open research findingslong-term effects of carbohydrateslongitudinal study on nutrition and agingmidlife nutrition and health outcomesphysical health and dietary choicesTufts University aging researchwomen’s health and nutrition studies
