Computational study designs multi-epitope vaccine candidate against Lassa virus
A computational reverse vaccinology study reports the design and in silico evaluation of a multi-epitope subunit vaccine candidate targeting the ...
Tag: Vaccine design
AI Framework Aims to Transform Helicobacter pylori Care from Diagnosis to Vaccines
A new review proposes a five-module artificial intelligence framework linking endoscopic diagnosis, genomic resistance prediction, vaccine design and digital adherence ...
Experimental Multi-Epitope Vaccine Shields Mice and Chickens Against Salmonella Enteritidis
A computationally designed multi-epitope subunit vaccine called FLPD protected 65 percent of mice and 70 percent of chickens against lethal ...
Computational Vaccine Designed to Target Tapeworm Infections in Livestock
Scientists have computationally designed a multi-epitope chimeric vaccine candidate against Taenia tapeworms in livestock, with all results so far limited ...
Computational Design Yields Multi-Epitope Tuberculosis Vaccine Candidate Fused to Bacterial Enterotoxin Fragment
A computational study has designed a multi-epitope tuberculosis vaccine candidate from conserved immunoreactive peptides, fused to a non-toxic enterotoxin fragment ...
Computational Design Yields Two mRNA Vaccine Candidates Against HMPV Glycoprotein
Researchers used immunoinformatics to design two multi-epitope mRNA vaccine candidates targeting the human metapneumovirus glycoprotein, reporting favorable predicted antigenicity, safety, ...
Booster Vaccine Platform Shapes the Breadth and Durability of SARS-CoV-2 T-Cell Immunity
A nine-month Ghanaian cohort study finds that adenoviral-vector boosting sustains broader and more durable SARS-CoV-2 T-cell epitope recognition than mRNA ...
Geographically Tailored Vaccine Design Could Reshape the HIV Immunization Paradigm
A new computational framework integrates regional HIV subtype diversity and host HLA allele frequencies to prioritize geographically tailored vaccine epitope ...
Head-to-Head Comparison Reveals mRNA Vaccines Behave Differently in Human Blood
Australian researchers have completed the first head-to-head comparison of three mRNA-lipid nanoparticle vaccine platforms in human blood, revealing key differences ...
Cryo-EM Reveals How FMDV O/Cathay Variants Evade Neutralizing Antibodies
Cryo-electron microscopy of porcine neutralizing antibodies bound to foot-and-mouth disease virus reveals how mutations on VP1 and VP3 drive antigenic ...
Hepatitis C Vaccine Design Gains Ground as Structures Reveal How Naive Antibodies See Viral Envelope
New structural and biochemical analyses of the hepatitis C virus E2 glycoprotein show that germline-reverted broadly neutralizing antibodies recognize the ...
Vaccination May Speed Up Influenza Evolution, Model Warns
A coupled epidemiological and evolutionary model of influenza shows that vaccination can accelerate viral escape and even raise infection incidence ...
Conserved Spike Epitopes Yield Antibodies That Neutralize Diverse Bat Sarbecoviruses
Researchers have mapped conserved epitopes on the sarbecovirus spike protein that allow three monoclonal antibodies to neutralize a wide range ...
Three Chikungunya Lineages, Three Mosquito Strategies: How Vector Adaptation Drives Global Spread
New phylogenomic analysis reveals that three ECSA sub-lineages of chikungunya virus each evolved distinct mosquito-adaptation strategies, explaining their regional dominance ...
Removing One Sugar Shield Makes Dengue Virus 2 More Visible to Potent Neutralizing Antibodies
A new cryo-EM and biophysical study shows that removing the N153 glycan from dengue virus 2 exposes previously hidden epitopes, ...
Injected Bacterial Antigens Program Gut Immune Memory Through Epithelial Cell Presentation
New research shows that bacterial proteins injected into gut epithelial cells, rather than those left on the bacterial surface, program ...
ImmunoStruct: Advancing Deep Learning in Immunogenicity Prediction
In the realm of immunology, the search for effective vaccines against infectious diseases and cancer has led to the exploration ...
