Review Details AMPK Roles in Gastrointestinal Cancers
A review in Cancer Cell International details how AMPK signaling acts as both a tumor suppressor and a promoter in ...
Tag: tumorigenesis
Review Details ACTN4 Role in Cancer and Therapeutic Targeting Strategies
A systematic review evaluates the role of the actin-binding protein ACTN4 in tumorigenesis and the challenges of targeting it in ...
Enzyme ZDHHC9 Drives Diffuse Gastric Cancer Growth by Regulating Cellular Iron Metabolism
Researchers have discovered that the enzyme ZDHHC9 promotes diffuse-type gastric cancer growth by stabilizing transferrin receptor 1 mRNA and enhancing ...
Gut Microbial Metabolite Suppresses Colorectal Cancer Growth in Preclinical Models
In preclinical models, gut bacteria producing the cholesterol metabolite 4-cholesten-3-one suppressed colorectal cancer growth and overcame resistance to targeted therapy.
ZNF169 Drives Thyroid Cancer Progression by Activating Downstream Effector FBXW10
Researchers found that the nuclear protein ZNF169 promotes thyroid carcinoma progression by binding the FBXW10 promoter and driving tumor proliferation.
EIF3I Promotes Gastric Cancer Growth by Stabilizing YAP and Altering Iron Metabolism
Researchers found that eukaryotic translation initiation factor 3 subunit I promotes gastric cancer progression by stabilizing YAP and driving intracellular ...
WTAP Modification of LINC00200 Drives Glioma Tumorigenesis Through Wnt Signaling Cascade
A newly published experimental investigation in Cell Division identifies a distinct epigenetic mechanism through which Wilms' tumor 1-associating protein coordinates ...
HSF1 Protein Review Links Cell Division to Cancer
A 2025 review in Cell Division details how heat shock factor 1 regulates cell division and drives tumorigenesis through metabolic ...
m6A RNA modification emerges as a key sculptor of the tumor microenvironment
A new open-access review describes how the m6A RNA modification acts as a key determinant in reshaping the tumor microenvironment ...
Review maps tumors linked to horseshoe kidney malformation
A review of 89 studies catalogs tumors linked to horseshoe kidney and adds the 39th reported renal neuroendocrine case.
Auxilin in Enteroendocrine Cells Keeps Intestinal Stem Cell Proliferation in Check
A study by Runqi Wang, Zhengran Li, Jing Wei, Jiajia Wang, Xiyue Liu Tao, Danjie Zhang, Ruiyan Kong, Xuejing Ren, ...
Two Molecular Machines, One Cancer Engine: How Deubiquitinases and m6A RNA Tags Talk to Each Other
A new review in Molecular Cancer maps the bidirectional crosstalk between deubiquitinases and m6A RNA modification, revealing a coupled regulatory ...
Vortex Defects in Cell Sheets Build Orderly 3D Tissues Layer by Layer
Physicists have shown that a vortex-shaped topological defect in a cell monolayer can drive millimetre-scale convergent flows that assemble cells ...
Hypermutation Gives Weak Cancer Drivers a Head Start, Study Finds
Mathematical modelling shows that elevated mutation rates and mutational biases, rather than altered selection, can explain why weak atypical KRAS ...
Long-Read RNA Sequencing Reveals Hidden Isoform Chaos That Gene-Level Cancer Studies Miss
A long-read RNA sequencing atlas of 144 paired tumor-normal samples across ten organs shows that gene expression changes converge across ...
AHCY–Adenosine Complex Boosts Fatty Acids, Cancer
In a groundbreaking study set to redefine our understanding of cancer metabolism and RNA modification, researchers have uncovered a novel ...
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