Excess of Extreme Baseline Distributions Found Across Consecutive Clinical Trials
An evaluation of 568 randomized controlled trials revealed that 26.2 percent displayed extreme baseline distributions, substantially exceeding the 10 percent ...
Tag: research methodology
Methodological Framework Proposed to Standardize Ayurvedic Clinical Trial Protocols
Researchers have proposed a methodological framework and eleven candidate reporting extensions to adapt clinical trial protocol standards for Ayurvedic whole-system ...
Medicaid claims data offers a smarter way to find and recruit providers for qualitative research
Researchers used New York State Medicaid pharmacy claims to identify and recruit 104 high-volume providers of medication for opioid use ...
Psycho-oncology trials largely ignore sex and gender reporting standards, review finds
A systematic review of 404 psycho-oncology randomized controlled trials found that more than half misused sex and gender terminology and ...
Registry Studies Rarely Test How Missing Patient Data Could Reverse Their Findings
A scoping review of 61 registry-based PROM studies found no reported tipping-point analyses and only one delta adjustment, prompting a ...
How to Write a Discussion Section That Readers Actually Trust
A new open-access guide breaks the Discussion section of clinical and epidemiological papers into six purposeful elements, from summarizing findings ...
How to Write Methods and Results Sections That Readers Can Trust
A new guide lays out ten steps for structuring the Methods section and six for the Results section of clinical ...
Platform Trials Promise Faster Answers but Face Serious Methodological Pitfalls
A new review finds adaptive platform trials offer real efficiency gains but are often undermined by weak blinding, non-concurrent controls ...
Tiered framework proposed to match clinical trial data sharing to scientific purpose
A BMC Medicine debate article proposes a three-tier framework linking released clinical trial data to the reproducibility and reuse it ...
Researchers propose ‘measurement validity induction’ as a concept describing a risk in scale use
A new conceptual paper in BMC Medical Research Methodology introduces 'measurement validity induction' to describe the risky practice of using ...
Educational Robotics After School Shows Promise, But Evidence Remains Shaky, Review Finds
A systematic review of 15 studies finds largely positive but methodologically fragile evidence for educational robotics programs in after-school and ...
LLM Framework Maps an Uneven Evidence Base on Air Pollution and Cognition
A human-validated LLM-assisted role-analysis framework found that the post-2020 air pollution and cognition literature is volume-rich but structurally uneven.
Researchers Rethink Global Health Methods Through Dialogic, Non-Extractivist COVID-19 Study
Researchers in Brazil, Peru, Canada and Germany describe a dialogical, non-extractivist approach to studying community mobilization during the COVID-19 pandemic.
Six-part framework aims to clarify clinical trial outcomes
A methodology study developed and pilot-tested a six-element framework for defining clinical trial outcomes completely and consistently.
AI Could Transform Nanotechnology Literature Reviews, but Maps Need Validation
A methodological review finds that artificial intelligence could make nanotechnology literature reviews faster and richer, but only if researchers validate ...
Scientific Bias Leaves Most Earth’s Species Unstudied
New research from the University of New South Wales reveals that scientific bias leads to the neglect of most species, ...
AI Reviewers Match Human Experts in Landmark Scoping Review Test
Artificial intelligence has been creeping into the machinery of science for years, but a new benchmark from Johns Hopkins researchers ...
AI Meets Human Expertise to Map How Mixed Forests Deliver Ecosystem Services
Researchers combined a retrieval-augmented GPT-4o agent with expert oversight to conduct a scoping review of how plant functional traits shape ...
Resveratrol Targets HLA-A in Diabetic Retinopathy Treatment
In a groundbreaking study led by a team of researchers including Lin, J., Liang, F., and Liu, Y., the complex ...
