Gene Importance Does Not Predict Mutation Rates in Bacteria and Yeast
A multiple-parameter controlled analysis of wild-type Escherichia coli and Saccharomyces cerevisiae demonstrates that genic importance, protein levels, and replication strand ...
Tag: protein abundance
Study Finds Important Microbial Genes Do Not Have Slower Mutation Rates
A study in PLOS Biology finds that essential genes in bacteria and yeast do not mutate at lower rates than ...
New Scanning Platform Maps Allosteric Pockets in Disease-Linked Transcription Factors
A high-throughput bacterial scanning method charts allosteric networks and druggable pockets across human transcription factor DNA-binding domains.
Fibroblast Tests Improve Diagnosis of Mitochondrial Disease
A study in EMBO Molecular Medicine shows that comprehensive functional testing in fibroblasts significantly improves the diagnosis of primary mitochondrial ...
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