Tag: polygenic risk score

A genome-wide study of more than 140,000 UK Biobank surgery patients identified a PITX2 risk locus for postoperative atrial fibrillation ...

In 216 Pakistani children with ALL, a weighted five-variant polygenic score discriminated anthracycline-induced cardiotoxicity far better than an unweighted score, ...

A new review argues that prenatal genomic testing can detect autism-linked variants but cannot predict autism in an individual fetus.

A combined analysis of CHARLS and the UK Biobank links restless sleep, poor sleep patterns and high genetic susceptibility to ...

A study of more than 21,000 Canadian adults links higher blood pressure to higher intraocular pressure and finds genetic evidence ...

A sweeping editorial on a 2024–2025 research collection describes how long-read sequencing, newborn screening, population genomics, and functional studies are ...

A trans-ancestry meta-analysis of 1,697,458 people identified 116 genetic risk loci for gallstone disease, including 59 previously unreported loci.

An MRI-based meta-analysis of 71,488 people of European ancestry identified 60 loci associated with liver triglyceride content and linked polygenic ...

A new trans-ancestry polygenic risk score built by fusing East Asian and European genome-wide association data markedly improves coronary artery ...

A 20-year cohort study links higher circulating PDGFD levels to increased atherosclerotic cardiovascular disease risk and simulates substantial risk reductions ...

A prospective study of over 336,000 UK Biobank participants links high allostatic load to elevated lung cancer risk, especially small-cell ...

A hybrid long-read and short-read sequencing study has identified a common CCG repeat in the FAM193B promoter as a genome-wide ...

Researchers combined single nucleus RNA-sequencing with GWAS and UK Biobank data to show that an obesity-linked variant in SREBF1 allele-specifically ...

A study of 420 Brazilian adults links variants in ADRB3, LEPR, FTO and PPARG to metabolic syndrome and shows that ...

A large UK Biobank cohort study finds that a sweet-tooth dietary preference profile is associated with sharply higher dementia risk, ...

A prospective cohort study of 7,614 Chinese adults links frequent and severe infection trajectories to accelerated biological aging and higher ...

In a groundbreaking advancement within the field of oncology, particularly in the realm of breast cancer research, a new study ...