Automated hospital records tool lifted adverse drug reaction reporting fortyfold
An automated reporting tool embedded in two Sydney hospitals' electronic medical records increased adverse drug reaction reports to Australia's regulator ...
Tag: Pharmacovigilance
Brazil’s VigiMed database reveals radiopharmaceutical safety reporting patterns
A retrospective analysis of Brazil's VigiMed database identified 191 radiopharmaceutical drug entries in 126 adverse event reports, with Xofigo and ...
Study maps barriers to COVID-19 vaccine safety surveillance in Kenya, South Africa, and Canada
A qualitative study in Kenya, South Africa, and Canada identified facilitators and barriers to COVID-19 vaccine safety surveillance and research ...
Schizophrenia Linked to a Fragile Cardiac Regulatory State in Donor Hearts
A donor-heart study finds that schizophrenia is associated with a cardiomyocyte state in which molecular output is preserved but regulatory ...
Breast Cancer Drug Analysis Flags Dementia Signals for Anastrozole in Women Over 50
A large pharmacovigilance analysis of FDA adverse event reports found no overall dementia risk signal for endocrine and targeted breast ...
Pneumonia emerges as the most reproducible respiratory warning sign across four BTK inhibitors
A dual-database pharmacovigilance analysis of FAERS and JADER found that pneumonia was the most reproducible respiratory adverse-event signal across four ...
FAERS study finds skin-cancer reporting signals for select interleukin inhibitors
A FAERS pharmacovigilance study found disproportionate skin-cancer reporting for risankizumab, tildrakizumab and ustekinumab, but the spontaneous-report data do not establish ...
FAERS analysis identifies platelet and triglyceride signals for givinostat
A retrospective FAERS analysis of 321 givinostat reports identified platelet abnormalities and increased blood triglycerides as prominent safety signals but ...
Pharmacovigilance narrows non-jaw osteonecrosis signals to glucocorticoids and asparaginase
A report-level analysis of more than 20 million adverse-event records found that glucocorticoids and asparaginase were the only drug signals ...
Single-run benchmark finds AI liver-injury extraction errors
A single-run benchmark of 120 liver injury narratives found that AI systems produced parseable output while retaining potentially causality-distorting errors, ...
FAERS analysis maps early, diverse ifosfamide neurological adverse events
A FAERS analysis of 786 ifosfamide-related neurological reports found a strong encephalopathy signal, a median onset of two days and ...
Finerenone Safety Signals Identified in US and Japanese Reports
A dual-database pharmacovigilance analysis identified recurring renal and metabolic reporting signals for finerenone and flagged dizziness, abnormal liver-function results, increased ...
FDA-Approved RNA Drugs Show Mostly Mild Side Effects, But Long-Term Safety Data Remain Thin
A new cross-platform review of eighteen FDA-approved RNA therapeutics finds that adverse effects depend more on delivery chemistry and administration ...
Tocilizumab Rechallenge at Reduced Dose Still Triggers Fibrinogen Crash in Arthritis Patient
A case report shows tocilizumab-induced hypofibrinogenemia recurred in a rheumatoid arthritis patient even after the drug dose was substantially reduced.
Most Cancer Drug Side Effects May Not Be Preventable, Vietnamese Database Reveals
A year of pharmacovigilance reports from Ho Chi Minh City shows that of 253 confirmed adverse reactions to anticancer drugs, ...
FDA Database Study Flags Safety Signals for Widely Used HIV Drug Combination
One of the most widely prescribed HIV treatments in the world is now the subject of a large-scale safety review, ...
Rare Hearing Loss Signal Linked to Common Antibiotic Imipenem/Cilastatin
A new case report in BMC Infectious Diseases describes a 75-year-old patient who developed right-sided hearing loss within 24 hours ...
Hospital EHR alert system cuts dangerous drug–herb interactions in Thai study
Herbal medicines are no longer fringe therapy. Across hospitals in Southeast Asia, patients routinely combine conventional prescription drugs with herbal ...
Handwriting, Workload and Missing Digital Safeguards: Nigerian Clinicians Map the Roots of Medication Errors
A cross-sectional study of 450 healthcare professionals in Kwara State, Nigeria, finds that poor handwriting, communication gaps, and heavy workloads ...
China’s Drug Price Cuts Under Scrutiny: Massive Review Finds No Clear Evidence Procured Generics Perform Worse
A systematic review of 81 studies finds no evidence that China's volume-based procurement generics perform worse than originator drugs, though ...
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Tomographic Study Assesses Interzonal Toric Stability Across Different Corneal Zones
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Research report: Phytotoxic potential of Ranunculus testiculatus aqueous extract: physiological responses and molecular docking/putative ligand interactions with barley α-amylase
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High-fibre, fermented-food diet trial will test gut-brain route to easing adult ADHD symptoms
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Research report: Effects of a game-based exergame intervention on motor competence and balance in children with autism spectrum disorder: a multiple-baseline single-case experimental study