Tag: Pharmacokinetics

Researchers developed ebastine-loaded Solusome nanovesicle oral lyophilisates that disintegrate in seconds and raised the drug's oral bioavailability 3.21-fold in rats.

A retrospective study of neonates in a Chinese intensive care unit reveals a non-linear relationship between gestational age and initial ...

A seven-year prospective trial shows that oral S-1 plus cisplatin preserves overall 5-FU exposure and manageable toxicity in cancer patients ...

A validated fingertip microsampling method with individualized hematocrit-adjusted conversion can accurately monitor tacrolimus and mycophenolic acid in transplant recipients, offering ...

A new review finds that ginseng-derived ginsenosides show context-dependent effects on healthy and malignant blood cells in laboratory models, but ...

A comprehensive review maps how approved drugs—from anticancer agents to antidepressants—can be systematically repurposed to combat drug-resistant superbugs.

A 52-week phase 3 trial across six Chinese centers found agalsidase alfa was generally well tolerated, kept kidney and cardiac ...

A new pharmacokinetic review explains why the safety warnings attached to topical roflumilast, drawn largely from its oral COPD formulation, ...

Researchers found that fast-tempo, irregular-rhythm, atonal-harmony music reduced formation of the toxic acyl glucuronide of mycophenolic acid in rat liver ...

A comprehensive review finds that beta-lactam–macrolide combination therapy shows its clearest benefit in severe community-acquired pneumonia, while most proposed synergy ...

A new systematic review of 123 studies shows that pairing organ-on-chip devices with digital twin computational models is rapidly maturing ...

A new International Pediatric Association analysis reveals that none of five novel antifungal drugs in late-stage development has pediatric efficacy ...

Springer Nature has named ten editors of the Journal of Pharmaceutical Investigation as recipients of its 2026 Editor of Distinction ...

A new quantitative systems pharmacology model links glucosamine's joint-level exposure to cartilage biology and clinical outcomes, offering a mechanistic explanation ...

A new piglet study provides the first integrated characterization of isoflurane uptake and disposition kinetics, revealing that only 14.5 percent ...

A validated translational platform linking lesion drug penetration to Phase 3 trial outcomes offers a new way to design shorter ...

A cucurbituril host–guest formulation of ticagrelor boosts solubility, doubles systemic exposure, and shifts macrophages toward an anti-inflammatory state in preclinical ...

A solvent-free mechanochemical grinding technique locks carbamazepine into complexes with larch-derived arabinogalactan and licorice-derived disodium glycyrrhizate, boosting the epilepsy drug's ...

A prospective study of 79 hypothyroid patients finds that bariatric surgery raises levothyroxine requirements, increases hormone absorption, and enriches the ...

A Thai pharmacokinetic study of 55 critically ill patients establishes a two-compartment model showing that 12 grams of sulbactam per ...