NAT10 enzyme drives follicular atresia through ac4C modification of Tnc mRNA
A new study reports that NAT10-catalyzed ac4C modification stabilizes Tnc mRNA, inhibiting mitophagy and driving follicular atresia, with the NAT10 ...
Tag: Parkin
Magnesium Sulfate Shows Neuroprotective Effects in Mouse Model of Postoperative Cognitive Dysfunction
A new experimental study links magnesium sulfate's neuroprotective effects to AMPK/PINK1/Parkin signaling in postoperative cognitive dysfunction.
Parkin’s Metabolic Control Emerges as a Key Route to Tumor Suppression
A new open-access review summarizes evidence that the PARK2-encoded E3 ubiquitin ligase Parkin suppresses tumors by regulating mitochondrial function, redox ...
Salidroside Protects Bovine Mammary Cells From Inflammation by Activating Mitophagy
A new cell-culture study reports that salidroside protects bovine mammary epithelial cells from LPS-induced inflammatory injury by activating AMPK/mTOR signaling ...
Traditional Chinese formula blocks liver cancer cell survival by disabling mitochondrial recycling
A preclinical study reports that the herbal formula Xiaoai Jiedu recipe suppresses PINK1-mediated mitophagy and activates NLRP3 inflammasome signaling in ...
High-Salt Diet Impairs Memory in Aged Mice by Overwhelming Mitochondrial Cleanup
A two-month high-salt diet impaired learning and memory in aged male mice and increased amyloid-beta accumulation, activating a PINK1/Parkin mitophagy ...
Lactate modification drives mitochondrial damage and fibrosis in diabetic hearts
A new study links lactate-driven protein lactylation to impaired mitochondrial cleanup and activated TGF-β1 signaling, offering a dual mechanism for ...
AAV gene replacement restores Parkin pathway activity in preclinical tests
An AAV carrying functional human PRKN restored mitochondrial-pathway signaling in Parkin-deficient cells and patient fibroblasts, while rodent tests showed that ...
Machine learning and cell study link shikonin to Parkin-dependent activity in hypoxic triple-negative breast cancer
A machine-learning and cell-culture study found that shikonin induced necroptosis and apoptosis in hypoxic MDA-MB-231 breast cancer cells through a ...
Brief Limb Ischaemia Cycles Shield the Kidneys by Switching On a Mitochondrial Cleanup Pathway
New research shows that remote ischaemic preconditioning protects kidneys from reperfusion injury by activating SIRT3-dependent, Parkin-mediated mitophagy in renal tubular ...
Fibrosis Signal BMP4 Drains Kidney Cells’ Mitochondrial Power in Diabetic Disease
New research shows that the pro-fibrotic signal BMP4 drives mitochondrial dysfunction in kidney mesangial cells by suppressing Parkin, a key ...
Disc Degeneration Traced to a Histone Switch That Silences the Cell’s Mitochondrial Cleanup Crew
A new study shows that the chromatin protein CBX3 accelerates disc degeneration by silencing the SESN2 gene through H3K9me3 marks, ...
Gut Bile Acid Rejuvenates Aging Bone Stem Cells to Fight Postmenopausal Osteoporosis
A gut bacteria-derived bile acid called hyodeoxycholic acid restores aging bone marrow stem cells and reverses bone loss in a ...
How Pathogens Hijack Mitophagy and What It Means for Treating Infection
A new review details how bacteria and viruses hijack or block the mitochondrial quality-control pathway of mitophagy to survive, evade ...
SRT1720 Alleviates Depression and Boosts Mitophagy in Mice
In recent groundbreaking research published in BMC Neuroscience, researchers led by Sun, L., Li, C., and Shi, J. have unveiled ...
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