GFAP mutations selectively reshape lipids in Alexander disease cell model
A targeted lipidomic study in engineered human astrocytoma cells found that Alexander disease-associated GFAP mutations caused distinct, extensive changes in ...
Tag: neurodegeneration
Shared Pathways Link Autism and Alzheimer’s, but Causality Remains Unproven
A 2026 review identifies shared pathways involving synapses, immunity, metabolism, epigenetics and waste clearance in autism and Alzheimer’s disease, while ...
Theobromine Shows Parkinson’s Promise, but Human Evidence Remains Thin
Biochemical and animal studies suggest that cocoa-derived theobromine can affect monoamine oxidase, adenosine and neuronal signaling, but no clinical evidence ...
Two Blood Proteins Could Let Doctors Stage Alzheimer’s Disease With a Simple Draw
A new Nature Communications study shows that plasma eMTBR-tau243 and p-tau205 rise during the later tau aggregation stage of Alzheimer's ...
Gut-Brain Homeostatic Continuum: A Systems Framework for Alzheimer’s Disease Resilience and Progression
A new conceptual framework called the Gut-Brain Homeostatic Continuum reframes Alzheimer's disease as a progressive erosion of organismal resilience driven ...
Alzheimer’s Breakthrough Clue: How the Cell’s Waste Disposal System Breaks the Brain’s Amyloid Pump
A new review argues that the ubiquitin-proteasome system degrades P-glycoprotein at the blood-brain barrier, impairing amyloid-beta clearance and offering new ...
Hidden Metabolite Switches on RNA Draw $5.5 Million NIH Transformative Award
Weill Cornell Medicine's Dr. Samie Jaffrey has received a five-year, $5.5 million NIH Director's Transformative Research Award to map how ...
Walking Patterns Reveal Alzheimer’s Risk Differently in Women and Men, Study Finds
A new study of 253 older adults finds that amyloid pathology alters gait and hippocampal structure in sex-specific ways during ...
Lab-grown human stem cells reveal a shared origin for the brain and body’s immune sentinels
A human stem-cell model recreates early yolk sac immune development and shows that a single progenitor population can generate specialized ...
How a Richer Environment Rewires the Brain’s Chemistry: New Review Maps Environmental Enrichment Across Neurotransmitter Systems
The distinction between the well-characterized and poorly-characterized neurotransmitter effects of environmental enrichment deserves closer examination, because it reveals something important ...
Ginsenoside Rg3 Extends Lifespan in Worms by Rewiring Lysosomal and Autophagy Pathways
A ginseng compound slowed neuronal aging in Caenorhabditis elegans through phosphoinositide signaling, TOR suppression, and HLH-30/TFEB activation, offering a new ...
Cochlear macrophages emerge as central drivers and therapeutic targets in age-related hearing loss
Age-related hearing loss, or presbycusis, has long been viewed as an inevitable consequence of wear and tear on the delicate ...
Biofilm-Forming Gut Bacterium Slows Nerve Cell Aging in Worms, Study Finds
A biofilm-proficient Bacillus subtilis strain delayed aging-related structural damage in the cholinergic neurons of C. elegans, with effects enhanced by ...
Transparent Fish, Hidden Damage: Zebrafish Reveal How Obesity Breaks Brain Synapses
A new review argues that the optically transparent zebrafish offers a uniquely powerful translational model for decoding how obesity dismantles ...
Subtle Shape Shifts, Not Misfolding: How FUS Mutations Drive ALS
A computational study shows that ALS-linked FUS mutations cause disease through subtle, site-specific changes in protein flexibility and molecular recognition ...
Landmark Study Reveals How Cellular Recycling Falters in Parkinson’s Disease
A new study reveals that impaired proteasome function, driven by SUMOylation, may underlie the toxic accumulation of alpha-synuclein in Parkinson's ...
White Matter Is Not Silent: Hidden Brain Networks Shift Early in Alzheimer’s Disease
A large resting-state fMRI study of 789 ADNI participants shows that white matter functional networks are measurably and selectively disrupted ...
When a Stroke Is Not a Stroke: MRI and Spinal Fluid Biomarkers Untangle Fatal Prion Disease Masquerading as Ischemic Attack
A new case report details how a 76-year-old man's sporadic Creutzfeldt-Jakob disease was initially misdiagnosed as ischemic stroke, with MRI ...
New AI Pipeline Watches Tens of Thousands of Synapses Fire at Once
Researchers in Berlin have developed an automated calcium imaging pipeline that detects and quantifies activity across tens of thousands of ...
Gene-Linked Parkinson’s Disease Moves Faster: Landmark Chinese Cohort Tracks Its Fingerprint
A three-year study of 301 Parkinson's disease patients in Northeast China finds that GBA1 gene variants, present in 8.31 percent ...
POPULAR NEWS
-
Postpartum Care Demands Hinder Home Blood Pressure Monitoring
-
Fujian Multi-Source Surveillance Tracks Timing and Concordance Across Two COVID-19 Waves
-
Competing Nucleation and Dilution Effects Govern Eggshell Cement Additives, Review Finds
-
Impaired Peptide Amidation Enzyme Activity Predicts Incident Alzheimer’s Disease Risk