Tag: Mycobacterium tuberculosis

A ten-year analysis of 9,665 tuberculosis isolates from Zhengzhou, China, finds overall drug resistance rising from 17.29 percent to 22.98 ...

Two LAMP-CRISPR diagnostic pipelines for Mycobacterium tuberculosis reached a limit of detection of 10 copies per microlitre, with the Cas12a ...

A study analyzing 699 M. tuberculosis isolates from 2018 and 2023 in Ecuador found only one Beijing sublineage isolate, which ...

A surveillance study of 699 tuberculosis isolates from Ecuador found the drug-resistance-associated RDRio genotype at 5.72 percent prevalence, stable from ...

A national genomic survey of 1,281 Mycobacterium tuberculosis isolates reveals four major lineages, high isoniazid and rifampicin resistance, and the ...

A new review argues that virtual screening and AI-driven modeling have expanded the search for anti-tuberculosis drugs, but persistent mismatches ...

A retrospective study of 334 patients found that lymph nodes at least 1.5 centimeters wide and pus specimens were independently ...

Mouse infection experiments show that Mycobacterium tuberculosis remains difficult for innate immunity to clear across ultra-low-dose, microbiota-primed, and Legionella-primed models.

A retrospective analysis of 4,351 Ethiopian hospital records found no statistically significant five-year trend in MTB detection or rifampicin resistance, ...

A phage-display and computational screen prioritized 14 Mycobacterium tuberculosis fragments as candidate HLA-E ligands, but experimental validation is still required.

Whole-genome analysis of two Iraqi pre-XDR tuberculosis isolates identified distinct lineages, established drug-resistance mutations and differences in genes associated with ...

Pulmonary tuberculosis remains one of the world's most stubborn infectious diseases, and a central challenge for clinicians is telling apart ...

A rat model study shows that hypoxia modulates IL-12 and IFN-γ cytokine dynamics during mycobacterial infection, with early IFN-γ levels ...

A large Chinese cohort study found that both metagenomic and targeted next-generation sequencing of lung fluid outperformed conventional tests for ...

Researchers have developed fluorescence polarization and thermal shift screening methods to identify small-molecule bait ligands for the bacterial ClpC N-terminal ...

A new PLOS Pathogens study finds that the microRNA-1246 regulates macrophage lipid metabolism and helps explain why some household contacts ...

A large genomic analysis of Mycobacterium tuberculosis Lineage 3 reveals six distinct sublineages, evidence of local transmission in Europe, and ...

A tuberculosis toxin that destroys only the tryptophan transfer RNA tricks the bacterium into boosting amino acid synthesis while preserving ...

A five-year Chinese hospital study of 5,123 women with tuberculosis shows that genital tuberculosis overwhelmingly strikes women in their twenties, ...

A large Chinese study of 448 children and young adults finds the QuantiFERON-TB Gold Plus blood test useful for diagnosing ...