Disrupting Chromatin Boundaries Regulates Mammalian NOTCH1 Expression Based on Epigenetic Context
Researchers found that deleting boundary elements around the conserved NOTCH1 chromatin domain reshapes gene expression and cellular growth in a ...
Tag: mouse embryonic stem cells
RNA-binding protein MSI1 keeps stem cells pluripotent by steering iron to DNA demethylation machinery
A new study shows that the RNA-binding protein MSI1 stabilizes the ferritin-like transcript Fthl17c, preserving the ferrous iron supply that ...
Scientists map where Polycomb memory is rebuilt in stem cells
A new study maps about 1,100 sites where PRC2 rapidly re-establishes itself in mouse embryonic stem cells after reversible depletion ...
SV40LT mouse fibroblast line retains feeder function without detected tumors
A C57BL/6J-derived SV40LT-immortalized fibroblast line sustained proliferation, supported R1/E mouse embryonic stem-cell self-renewal and retained tri-lineage differentiation potential without detectable ...
Hmgn3 Essential for Triggering Totipotency in Mouse Embryonic Stem Cells
In the rapidly evolving field of developmental biology, mouse embryonic stem cells (ESCs) have served as indispensable tools, primarily due ...
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