Tag: METTL3

Knocking down Hakai in colorectal cancer models reshapes RNA methylation of immune transcripts and alters immune marker expression in patient-derived ...

Investigators have identified an epigenetic mechanism in esophageal squamous cell carcinoma where METTL3-mediated m6A modification of the long non-coding RNA ...

Direct RNA sequencing of failing hearts reveals dynamic m6A remodeling and shows how transcript isoform switching drives apparent epitranscriptomic alterations ...

A new review details how the RNA modification m6A influences cell death, inflammation and risk factors in aortic dissection, pointing ...

A new review in Molecular Cancer maps the bidirectional crosstalk between deubiquitinases and m6A RNA modification, revealing a coupled regulatory ...

Researchers at Nanjing Medical University report that the m6A-stabilized circular RNA circLPAR3 suppresses ferroptosis through the PCBP2/CHAC1 axis, driving docetaxel ...

New research shows that the Super Elongation Complex drives both stem cell reprogramming and neural differentiation by releasing paused RNA ...

A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...

New research shows that the m6A-writing enzyme METTL3 speeds recovery from bacterial liver abscesses by methylating Nrf2 mRNA, which arms ...

A new study reveals how hypoxia-driven ER-mitochondria contact sites and the membrane-rupturing protein NINJ1 conspire to destroy the gastric lining ...

Recent research has made significant strides in unveiling the molecular underpinnings of osteosarcoma, a challenging and aggressive bone malignancy predominantly ...

Cells carry within them a remarkable and intricate blueprint encoded in DNA, a molecular instruction manual that dictates the proteins ...