Viral protein hijacks a metabolic enzyme to drive Kaposi’s sarcoma spread
Researchers have shown that the KSHV protein vIRF3 binds and activates the metabolic enzyme PKM2, raising acetyl-CoA levels that drive ...
Tag: Metabolic Reprogramming
How Lung Cancer Rewires Fat Metabolism to Grow, Spread, and Evade Treatment
A new review in the Journal of Translational Medicine maps how non-small cell lung cancer rewires lipid metabolism to fuel ...
How a Single Amino Acid Pathway May Steer Autoimmune Disease
A new review in the Journal of Translational Medicine details how the glutamine-glutamate metabolic axis regulates immune cell fate and ...
A Lipid Dial May Decide Whether Bile Duct Cancer Cells Live or Die by Ferroptosis
A new review proposes that the ratio of monounsaturated to polyunsaturated membrane phospholipids acts as a tunable rheostat controlling ferroptosis ...
Sugar Metabolism Emerges as a Master Switch Controlling Bone Rebuilding
A new review argues that glycolysis acts as a signaling hub in bone remodeling, with glycolytic enzymes and metabolites such ...
Gut Viruses May Act as Ecological Amplifiers of Colorectal Cancer
A new review proposes that bacteriophages in the gut virome act as ecological amplifiers, translating environmental disturbances into bacterial reprogramming ...
AKT1 Epigenetics Drive Metabolic Shift in Lipedema
Recent research has unveiled significant advancements in our understanding of lipedema, a chronic condition characterized by an abnormal accumulation of ...
Injectable Hydrogels Reprogram Metabolism to Prevent Osteomyelitis
In a transformative leap for orthopedic medicine, researchers have developed a novel injectable hydrogel therapy that not only targets osteomyelitis ...
Amino Acid Metabolism: New Hope for Cholangiocarcinoma
Cholangiocarcinoma (CCA), particularly its intrahepatic subtype (iCCA), remains one of the most formidable challenges in oncology today. This malignancy is ...
FASN Drives Immunosuppression in DLBCL Tumors
The intricate relationship between cellular metabolism and immune regulation has long been a focal point in cancer research, especially within ...
Dietary Restriction Boosts CD8+ T Cell Cancer Immunity
In a groundbreaking study that bridges nutrition, immunology, and oncology, researchers have unveiled compelling evidence that dietary restriction can fundamentally ...
New Two-Drug Combination Shows Promise in Enhancing Colorectal Cancer Treatment
In a groundbreaking advancement in the fight against colorectal cancer, researchers from the University of Barcelona have unveiled a promising ...
Nitric Oxide Drives Metabolic Shift in Macrophages
In the intricate world of immunology, macrophages stand as pivotal sentinels of the innate immune system, capable of rapidly adapting ...
Mapping Breast Cancer Metabolism: Paving the Way for Innovative Targeted Therapies
Breast cancer continues to stand as one of the most formidable health challenges facing women globally. Despite advances in detection ...
