Lutetium-177 Therapy Reshapes the Protein Landscape of Neuroendocrine Tumors
Proteomic profiling of GOT1 neuroendocrine tumors after lutetium-177 DOTATATE therapy reveals suppressed invasion pathways and altered p53 and stress signaling ...
Tag: mass spectrometry
Google.org backs University of Toronto team with $2.3 million to build OpenPep, an AI engine for peptide drug discovery
A University of Toronto-led team will use a $2.3 million Google.org award to build OpenPep, an open-access database and AI ...
Same Blood, Different Verdicts: EQA Reveals Widespread Cortisol Interpretation Variation
A nationwide external quality assessment exercise reveals that UK laboratories disagree on diagnosing adrenal insufficiency from the same cortisol samples, ...
Billion-Spectrum AI Corpus Pushes Proteomics Into the Deep Learning Era
Researchers have unveiled MassNet, a corpus of 1.5 billion mass spectra across 35 species, and a new transformer model that ...
Fifty-Year-Old Urine Drug Tests Are Misleading Doctors and Harming Patients, Experts Warn
Physicians warn that decades-old immunoassay-based urine drug tests routinely produce false results that mislead clinicians and harm patients, calling for ...
Two Common Cheese Additives Push Milk Protein Browning in Opposite Directions
New research shows that two widely used dairy phosphate salts steer the Maillard browning of casein in opposite directions, with ...
Ovarian Cancer’s Hidden Weakness: An Arginine Gateway on the Cell Surface
A detailed map of proteins on the surface of high-grade serous ovarian cancer cells has revealed that these tumors depend ...
Chemists Build a Modular Platform That Sorts the Metabolome by Reactivity
A new modular reactivity-encoding platform sorts metabolites by functional group before mass spectrometry, boosting detection limits by up to 40,000-fold ...
Habitat, Not Hidden Genes, Drives Coral Chemistry Under Heat Stress
A reciprocal transplant experiment in the Florida Keys reveals that the environment, not cryptic genetic lineage, is the strongest driver ...
Saliva Proteomics Points to New Biomarker Candidates for Hepatitis B and C
A label-free salivary proteomics study identifies increased IgG Fc-binding protein and decreased haptoglobin, prolactin-inducible protein, submandibular gland androgen-regulated protein 3, ...
Beetles Repurpose a Famous Pigment Gene to Build Homes for Their Bacteria
Scientists have discovered that tortoise beetles repurpose the Yellow pigment protein, famous for fruit fly colouration and behaviour, to build ...
Sniffing Out Trouble: Scientists Detect Pest Attacks on Maize in Real Time by Reading Plant Odors
Researchers have shown that real-time mass spectrometry and electronic noses can detect the chemical distress signals maize plants emit when ...
From Ancient Rocks to Cancer Wards: Stable Isotopes Emerge as Mechanistic Biomarkers
A new review argues that stable isotope fractionation patterns, long used to reconstruct Earth's history, could become mechanistic biomarkers for ...
Spirulina’s Blue Pigment Protein Can Trigger Allergy, but Digestion Weakens Its Grip
A University of Parma study shows that Spirulina's major pigment-protein C-phycocyanin binds IgE from sensitized patients but loses much of ...
Rare Heavy Nitrogen Pairs Reveal Hidden Microbial Loss From Water
UCLA-led researchers show that rare pairs of heavy nitrogen atoms act as a natural fingerprint for microbial nitrogen removal, a ...
Proteomics and machine learning expose hidden toxicity in protein degrader drugs
High-throughput proteomics and machine learning revealed that cereblon-recruiting androgen receptor degraders inhibit mitochondrial complex I, and guided linker modifications that ...
BRCA Carriers Show Distinct Protein Signatures in Healthy Breast Tissue, Study Finds
A Mayo Clinic-led proteomic study of nearly 5,000 proteins in nonmalignant breast tissue reveals that cancer-free BRCA1/2 mutation carriers show ...
Order Beats Time: AI Cracks Retention Prediction Across Any Chromatography Setup
Researchers have developed a two-step machine-learning method that predicts small-molecule retention times in liquid chromatography for any experimental setup without ...
Mass Spectrometry Uncovers Hidden Bacterial Targets of Tularemia Immunity
Using mass spectrometry-based immunopeptidomics, researchers identified 57 MHC-II peptides from 23 Francisella tularensis proteins and pinpointed ten immunogenic CD4 T ...
Rare Nitrogen Molecules Reveal Hidden Microbial Losses in Earth’s Nitrogen Cycle
Biogeochemists have shown that rare doubly heavy nitrogen-15 molecules act as a natural fingerprint of microbial nitrogen removal, offering a ...
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