IGF2BP3 stabilizes TROAP mRNA and suppresses ferroptosis in non-small cell lung cancer
A new study reports that the m6A reader protein IGF2BP3 promotes non-small cell lung cancer progression by stabilizing TROAP mRNA ...
Tag: m6A modification
Cell Study Links RNA Modification WTAP to KDR Protection in Aneurysm Model
A cell study finds that WTAP upregulates KDR through m6A modification, protecting human brain microvascular endothelial cells from angiotensin II-induced ...
Tiny RNA Cargo From Bone-Eating Cells Shields the Hip From Alcohol Damage
Researchers report that alcohol depletes a protective microRNA in osteoclast-derived exosomes, and that restoring miR-378a-3p in rats reduces femoral head ...
Bioinformatics analysis prioritizes 2,505 Arabidopsis genes linking m6A and alternative polyadenylation
A multi-dataset bioinformatics analysis prioritized 2,505 candidate Arabidopsis genes associated with links between m6A RNA modification and alternative polyadenylation under ...
Interactions between circular RNAs (circRNAs) and the Hippo pathway in cancer
A 2026 review identifies multiple mechanisms through which circular RNAs regulate Hippo signaling and summarizes evidence linking them to cancer ...
NEK2 Drives Trastuzumab Resistance in Gastric Cancer Through m6A Control of FN1
New research reveals that the kinase NEK2 promotes trastuzumab resistance in gastric cancer by boosting WTAP/YTHDF1-dependent m6A modification of FN1 ...
Two Molecular Machines, One Cancer Engine: How Deubiquitinases and m6A RNA Tags Talk to Each Other
A new review in Molecular Cancer maps the bidirectional crosstalk between deubiquitinases and m6A RNA modification, revealing a coupled regulatory ...
Chemical Tag on RNA Helps Melanoma Dodge Ferroptosis, Study Finds
New research shows that the m6A reader protein YTHDF2 promotes melanoma progression by destabilizing HMOX1 mRNA and shielding tumor cells ...
RNA Chemical Tag Emerges as Hidden Driver of Kidney Damage in Diabetes
A new study shows that the RNA demethylase FTO stabilizes EGR1 mRNA through m6A modification, activating a STING1-driven inflammatory cascade ...
Lost tumor brake found to rewire liver cancer cell power plants
Researchers report that loss of the tumor suppressor LZTR1 stabilizes mitochondrial transcription factor A, reprogramming liver cancer cells toward complex ...
Chemical Tag on mRNA Emerges as Master Switch Behind Tumor Immune Evasion
A new review in the Journal of Translational Medicine details how the m6A RNA modification acts as a bidirectional switch ...
M6A Modification Influences Chromatin TADs in MLLr+ AML
In an exciting new study published in Molecular Cancer, researchers have uncovered the intricate relationship between RNA modifications and chromatin ...
M6A Modification Boosts Osteosarcoma Progression via Ca2+ Signaling
Recent research has made significant strides in unveiling the molecular underpinnings of osteosarcoma, a challenging and aggressive bone malignancy predominantly ...
CircSLC22A3 Blocks ESCC Spread via m6A Pathway
In a groundbreaking study published in BMC Cancer, researchers unveil the pivotal role of a circular RNA, circSLC22A3, in suppressing ...
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