Integrated single-cell and spatial transcriptomics reveal that recurrent hypopharyngeal squamous cell carcinoma undergoes cellular reprogramming driven by an IGF2BP2-SMAD3 axis, ...
A study demonstrates that the PIKfyve inhibitor APY0201 suppresses esophageal cancer cell invasion and stemness while inducing ferroptosis through the ...
Esketamine improved cognitive performance and suppressed neuronal apoptosis in perioperative neurocognitive disorder models by stabilizing DHCR24 expression through METTL3-mediated m6A ...
Researchers revealed that the RNA methyltransferase METTL16 cooperates with IGF2BP2 to stabilize LAMA4 and upregulate COL4A1, accelerating hepatocellular carcinoma progression ...
Local hyperthermia at 41 °C alleviates imiquimod-induced psoriasiform inflammation by activating an HSF1–METTL14–m6A–CRYAB regulatory axis that suppresses NF-κB signaling.
A new study reveals that histone lactylation promotes bone formation in postmenopausal osteoporosis by stabilizing the SMAD1 protein through an ...
Investigators have identified an epigenetic mechanism in esophageal squamous cell carcinoma where METTL3-mediated m6A modification of the long non-coding RNA ...
A study in Cell Biology and Toxicology reports that H3K18 lactylation promotes ALKBH5 transcription, which stabilises ATF6 mRNA through m6A ...
A newly identified mitochondrial long noncoding RNA, lncOriL, found in zebrafish and conserved in humans, may reveal an unrecognized layer ...
A narrative review proposes that food additives could alter gut microbes in ways relevant to glioblastoma, while stressing that no ...
A single-cell atlas of healthy and COPD lung tissue identifies an HSPA1B-positive inflammatory monocyte state whose transcriptional program is associated ...
A mouse and cell study finds that smoke inhalation lowers the m6A methyltransferase WTAP, which stabilizes pIgR messenger RNA and ...
Preclinical experiments show that METTL14 stabilizes FDX1 RNA through m6A methylation, promoting cuproptosis and suppressing clear cell renal cell carcinoma ...
Researchers at Nanjing Medical University report that the m6A-stabilized circular RNA circLPAR3 suppresses ferroptosis through the PCBP2/CHAC1 axis, driving docetaxel ...
A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...
A new review in Medical Oncology details how the RBM family of RNA-binding proteins acts as both tumor suppressors and ...
New research reveals that estrogen receptor alpha drives an m6A-dependent RNA stabilization pathway through HNRNPC and DDX6 that promotes the ...
New research shows that the m6A-writing enzyme METTL3 speeds recovery from bacterial liver abscesses by methylating Nrf2 mRNA, which arms ...
A new study reveals how hypoxia-driven ER-mitochondria contact sites and the membrane-rupturing protein NINJ1 conspire to destroy the gastric lining ...
In a groundbreaking advance poised to reshape the therapeutic landscape of oral squamous cell carcinoma (OSCC), recent research spearheaded by ...
