A novel cold organ preservation solution named Perla combines an extracellular sodium-rich formulation and polyethylene glycol with repurposed trimetazidine, carvedilol, ...
A narrative synthesis establishes a switch-aware framework showing that post-ischemic brain cell death is coordinated across time and anatomical compartments ...
Preclinical experiments demonstrate that OXSR1 deficiency attenuates ischemia-reperfusion-induced acute kidney injury and oxidative stress by inactivating the JAK2/STAT3 pathway.
New research links the enzyme ZDHHC12 to renal fibrosis by showing it modifies SMAD3 through palmitoylation, a key step in ...
A study combining preclinical models, human genetics, and patient data shows that SGLT2 inhibitors protect coronary microvascular function by preventing ...
Columbia University surgeons transplanted a beating, normothermically perfused pig heart into a baboon without any ischemic time, achieving nearly eight ...
Researchers identified the TLR2/TLR4-binding sequences of the matrix protein biglycan and showed that synthetic peptides carrying these motifs reduce inflammation ...
A cell-line study reports that sevoflurane post-conditioning protects rat cardiomyocytes from hypoxia/reoxygenation injury by downregulating LINC00173, freeing miR-490-3p to suppress ...
Adding the senomorphic drug ruxolitinib to cold storage solution improved contractile recovery in hearts from aged mice, with stronger effects ...
A new review finds that recipient factors such as durable LVAD support, amiodarone exposure, renal dysfunction and prior sternotomy consistently ...
A platelet-engineered AAV system that silences the fatty acid transporter CD36 reshaped cardiac lipid metabolism and improved repair after ischemia-reperfusion ...
Frontiers in Cellular Neuroscience has retracted a 2020 rat study claiming the grape pomace extract Taurisolo protects the brain from ...
A clinical study finds that mitochondrial function in leg muscle adapts after revascularisation only in earlier stages of peripheral arterial ...
A detailed cardiac MRI study of 518 heart attack patients finds that lipoprotein(a), a major genetic cardiovascular risk factor, shows ...
A new review argues that microvascular obstruction, the reason up to half of heart attack patients fail to achieve adequate ...
A new Forum article argues that the design of experimental warm ischemia models, from lung inflation state to split-lung laterality, ...
A new comprehensive review maps the signaling pathways, biomarkers, and molecular signatures that determine whether heart muscle survives ischemic injury.
Machine perfusion technologies are transforming abdominal organ transplantation from passive cold storage into active assessment, therapy, and regeneration, while raising ...
A rat study using fluorescent tracer dextrans shows that transplanted intestines preserve normal gut motility four weeks after surgery while ...
A new review proposes that five interlinked biological modules, unified by mitochondrial vulnerability, explain why aging livers with the same ...
