Tag: intervertebral disc degeneration

A narrative review synthesizes evidence on how immunometabolic crosstalk between immune cells and nucleus pulposus cells drives intervertebral disc degeneration.

A study published in Frontiers in Cell and Developmental Biology identifies CD36, SESN3, and HMOX1 as key oxidative stress-associated biomarkers ...

An injectable hydrogel carrying lab-grown cartilage microtissues preserved disc height and shifted anabolic and catabolic gene expression toward regeneration in ...

A new review maps how metabolite-driven protein modifications such as lactylation, O-GlcNAcylation and succinylation may link the disc's harsh metabolic ...

A pH- and ROS-responsive hydrogel carrying CRISPR-Cas9 silenced the TRPV4 calcium channel in rat discs, restoring autophagic flux and slowing ...

A 2026 perspective synthesizes human, animal and molecular evidence linking cellular senescence, oxidative stress, mechanical loading and microbiome changes to ...

A local genetic screen linked MST1, DLK1, ITIH1 and SAA1 to intervertebral disc-disorder outcomes, while single-cell tissue analysis and a ...

A new study shows that the chromatin protein CBX3 accelerates disc degeneration by silencing the SESN2 gene through H3K9me3 marks, ...

A new study shows that the rare sugar D-allose restores mitophagy, suppresses cGAS–STING signalling and preserves the cytoprotective peptide ADM2 ...

In the intricate world of cellular biology, pyroptosis has emerged as a captivating area of study, especially in its association ...

A groundbreaking study published in the September 2025 issue of Aging-US has unveiled a pivotal role of the transcription factor ...

In a groundbreaking correction published in the latest issue of Cell Death Discovery, researchers Wu, Song, Liu, and colleagues shed ...

In a groundbreaking study published recently in Cell Death Discovery, researchers have unveiled a novel molecular mechanism that accelerates the ...